◀ Back to CD47

CD47 — THBS1

Pathways - manually collected, often from reviews:

• KEGG ECM-receptor interaction: COMP/THBS1/THBS2/THBS3/THBS4 → CD47 (protein-protein, activation)
• NCI Pathway Database Beta3 integrin cell surface interactions: CD47 (CD47) → alphaIIb/beta3 Integrin/CD47/Thrombospondin complex (CD47-ITGA2B-ITGB3-THBS1) (modification, collaborate)
  Fujimoto et al., J Biol Chem 2003*, Plow et al., Blood 1985, Chung et al., J Biol Chem 1997
  Evidence: physical interaction
• NCI Pathway Database Beta3 integrin cell surface interactions: CD47 (CD47) → Thrombospondin complex (THBS1) (modification, collaborate)
  Fujimoto et al., J Biol Chem 2003*, Plow et al., Blood 1985, Chung et al., J Biol Chem 1997
  Evidence: physical interaction
• NCI Pathway Database Beta3 integrin cell surface interactions: alphaIIb/beta3 Integrin complex (ITGA2B-ITGB3) → alphaIIb/beta3 Integrin/CD47/Thrombospondin complex (CD47-ITGA2B-ITGB3-THBS1) (modification, collaborate)
  Fujimoto et al., J Biol Chem 2003*, Plow et al., Blood 1985, Chung et al., J Biol Chem 1997
  Evidence: physical interaction
• NCI Pathway Database Beta3 integrin cell surface interactions: alphaIIb/beta3 Integrin/CD47/Thrombospondin complex (CD47-ITGA2B-ITGB3-THBS1) → Thrombospondin complex (THBS1) (modification, collaborate)
  Fujimoto et al., J Biol Chem 2003*, Plow et al., Blood 1985, Chung et al., J Biol Chem 1997
  Evidence: physical interaction

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind Interaction: CD47 — THBS1 Moralez et al., J Cell Physiol 2005*
• IRef Bind_translation Interaction: CD47 — THBS1 (coimmunoprecipitation) Moralez et al., J Cell Physiol 2005*
• IRef Hprd Interaction: CD47 — THBS1 (in vivo) Chung et al., Blood 1999*, Gao et al., J Biol Chem 1996*, Chung et al., J Biol Chem 1997
• IRef Ophid Interaction: CD47 — THBS1 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Isenberg et al., J Biol Chem 2006 : Therefore, ligation of either CD36 or CD47 is sufficient to inhibit NO-stimulated vascular cell responses and cGMP signaling, but only CD47 is necessary for this activity of thrombospondin-1 at physiological concentrations
Sarfati et al., Curr Drug Targets 2008 : CD47 in the immune response : role of thrombospondin and SIRP-alpha reverse signaling
Miller et al., Matrix Biol 2013 : Therefore, engaging CD47 is necessary and sufficient for thrombospondin-1 to inhibit H2S dependent T cell activation