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IFNB1 — NAALADL1
Text-mined interactions from Literome
Coccia et al., Eur J Immunol 2004
:
TLR-9 stimulation by CpG DNA induced the expression of all IFN-alpha, -beta, -omicron and -lambda subtypes in pDC, whereas TLR-4 stimulation by LPS, or TLR-3 stimulation by poly
I:C ,
induced only
IFN-beta and IFN-lambda gene expression in MDDC
Brentano et al., Arthritis Rheum 2005
(Arthritis, Rheumatoid...) :
Stimulation of cultured RASFs with the TLR-3 ligand poly (
I-C )
resulted in the production of high levels of
IFNbeta , CXCL10, CCL5, and IL-6 protein
Pyo et al., J Leukoc Biol 1991
(Herpes Simplex...) :
Taken together these data indicate that the antiviral effects of Poly
I:C in inflammatory macrophages are
mediated solely by
IFN-beta , which acts in an autocrine manner to induce resistance to HSV-1
Harwani et al., Virology journal 2007
:
Poly
I:C ( a TLR3-ligand ) and lipopolysaccharide ( LPS, a TLR4-ligand )
inhibited HCMV and induced secretion of IL-8 and
Interferon-beta (IFNbeta) in both foreskin fibroblasts and ectocervical tissue
Sun et al., Dev Comp Immunol 2009
:
In mammals, poly
I:C induces
IFN-beta through the RIG-I/MDA5 or the TLR3 pathway, both of which are dependent on NF-kB
Flür et al., Am J Pathol 2009
(Glomerulonephritis...) :
In primary mesangial cells, poly
I:C RNA mediated
IFN-beta induction was partially TRIF dependent ; however, when poly I:C RNA was complexed with cationic lipids to enhance cytosolic uptake, mesangial cells produced large amounts of IFN-alpha and IFN-beta independent of TRIF
Uchida et al., J Physiol Sci 2012
:
Interferon-beta , but not tumor necrosis factor-alpha, production in
response to poly
I:C is maintained despite exhaustive exercise in mice