Gene interactions and pathways from curated databases and text-mining

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IFNB1 — NAALADL1

Text-mined interactions from Literome

Coccia et al., Eur J Immunol 2004 : TLR-9 stimulation by CpG DNA induced the expression of all IFN-alpha, -beta, -omicron and -lambda subtypes in pDC, whereas TLR-4 stimulation by LPS, or TLR-3 stimulation by poly I:C , induced only IFN-beta and IFN-lambda gene expression in MDDC
Brentano et al., Arthritis Rheum 2005 (Arthritis, Rheumatoid...) : Stimulation of cultured RASFs with the TLR-3 ligand poly ( I-C ) resulted in the production of high levels of IFNbeta , CXCL10, CCL5, and IL-6 protein
Pyo et al., J Leukoc Biol 1991 (Herpes Simplex...) : Taken together these data indicate that the antiviral effects of Poly I:C in inflammatory macrophages are mediated solely by IFN-beta , which acts in an autocrine manner to induce resistance to HSV-1
Harwani et al., Virology journal 2007 : Poly I:C ( a TLR3-ligand ) and lipopolysaccharide ( LPS, a TLR4-ligand ) inhibited HCMV and induced secretion of IL-8 and Interferon-beta (IFNbeta) in both foreskin fibroblasts and ectocervical tissue
Sun et al., Dev Comp Immunol 2009 : In mammals, poly I:C induces IFN-beta through the RIG-I/MDA5 or the TLR3 pathway, both of which are dependent on NF-kB
Flür et al., Am J Pathol 2009 (Glomerulonephritis...) : In primary mesangial cells, poly I:C RNA mediated IFN-beta induction was partially TRIF dependent ; however, when poly I:C RNA was complexed with cationic lipids to enhance cytosolic uptake, mesangial cells produced large amounts of IFN-alpha and IFN-beta independent of TRIF
Uchida et al., J Physiol Sci 2012 : Interferon-beta , but not tumor necrosis factor-alpha, production in response to poly I:C is maintained despite exhaustive exercise in mice