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IFNB1 — IL1RN

Text-mined interactions from Literome

Palmer et al., Ann Rheum Dis 2004 : Interferon beta stimulates interleukin 1 receptor antagonist production in human articular chondrocytes and synovial fibroblasts ... To investigate the effects of IFNbeta on the production of interleukin-1 receptor antagonist ( IL1Ra ) in human articular chondrocytes and synovial fibroblasts ... Consistently, IL1beta and IFNbeta induced sIL1Ra mRNA expression in chondrocytes, while expression of icIL1Ra1 was not detectable
Molnarfi et al., J Neuroimmunol 2004 : Here we compare modulatory effects of IFNbeta on the production of proinflammatory cytokines ( IL-1beta, IL-1alpha, TNF, and IL-6 ) and IL-1Ra in human monocytes stimulated by lipopolysaccharides (LPS) and isolated plasma membranes of stimulated T cells ( msHUT ), which are likely to reflect monocyte activation in acute and chronic inflammation, respectively ... In monocytes activated by either LPS or msHUT, IFNbeta did not modulate the secretion of IL-1alpha and IL-6, but it enhanced the production of IL-1Ra in a dose dependent manner
Comabella et al., J Neurol 2008 (Multiple Sclerosis, Chronic Progressive) : Although previous studies have shown induction of sTNF-RII and IL-1ra by interferon-beta (IFNbeta) in patients with relapse-onset forms of multiple sclerosis (MS), to date no studies of these cytokine inhibitors have been performed in patients with essentially progressive forms of MS ... To address the effects of IFNbeta on serum levels of sTNF-RII and IL-1ra in a cohort of progressive MS patients and to assess the relationship between levels and changes of sTNF-RII and IL-1ra and clinical and radiological variables
Wan et al., J Cell Mol Med 2008 (Carcinoma, Hepatocellular...) : In addition, IFN-alpha or IFN-beta significantly enhanced the stimulatory effect of IL-1beta on production of IL-1Ra
Mavragani et al., Arthritis Rheum 2010 (Arthritis, Rheumatoid) : Consistent with the capacity of IFNbeta to induce IL-1Ra , elevated baseline IL-1Ra levels were associated with better therapeutic outcomes ( odds ratio 1.82 [ 95 % confidence interval 1.1-3.29 ], P = 0.027 )
Nicoletti et al., Cytokine 1996 (Multiple Sclerosis...) : Moreover, to evaluate whether the beneficial effect of IFN-beta on the course of MS might also be mediated by an increased production of IL-1ra , we measured the levels of circulating IL-1ra in MS patients prior to and after 6 months of continuous treatment with natural human IFN-beta ( 6,000,000 IU three times a week for 6 months )
Coclet-Ninin et al., Eur Cytokine Netw 1997 : Interferon-beta not only inhibits interleukin-1beta and tumor necrosis factor-alpha but stimulates interleukin-1 receptor antagonist production in human peripheral blood mononuclear cells ... Simultaneously, IFN-beta increased the production of IL-1 receptor antagonist (IL-1Ra) by 37 % and did not modulate the release of TNF-soluble receptors (TNF-sRs) p55 and p75
Liu et al., J Immunol 1998 : IFN-beta induces IL-1Ra and augments LPS- and IL-4 induced IL-1Ra, but suppresses LPS- and IL-1 induced IL-1, shifting the balance toward the expression of the IL-1Ra