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IFIH1 — IFNB1

Text-mined interactions from Literome

Kang et al., Proc Natl Acad Sci U S A 2002 (Melanoma) : Protein kinase C activation by mezerein further augments mda-5 expression induced by IFN-beta ... Expression of mda-5 is controlled transcriptionally by IFN-beta , and the MDA-5 protein localizes in the cytoplasm
Kang et al., Oncogene 2004 (Melanoma) : IFN-beta , a type I IFN, induces mda-5 expression in a biphasic and dose dependent manner
Andrejeva et al., Proc Natl Acad Sci U S A 2004 : The V proteins of paramyxoviruses bind the IFN-inducible RNA helicase, mda-5 , and inhibit its activation of the IFN-beta promoter ... Overexpression of mda-5 stimulated the basal activity of the IFN-beta promoter in reporter gene assays and significantly enhanced the activation of the IFN-beta promoter by intracellular dsRNA ... Inhibition of mda-5 by RNA interference or by dominant interfering forms of mda-5 significantly inhibited the activation of the IFN-beta promoter by dsRNA
Berghäll et al., Microbes Infect 2006 : Forced expression of mda-5 , but not that of RIG-I or TLR3, leads to enhanced IFN-beta promoter activity in MV-infected A549 cells
Malathi et al., Nature 2007 (Cardiovirus Infections) : We show that small self-RNAs produced by the action of RNase L on cellular RNA induce IFN-beta expression and that the signalling involves RIG-I, MDA5 and IPS-1
Pichlmair et al., J Virol 2009 : Furthermore, RNA from cells infected with encephalomyocarditis virus or with vaccinia virus and precipitated with the anti-dsRNA antibody can bind to MDA5 and induce MDA5 dependent IFN-alpha/beta production upon transfection into indicator cells
Li et al., J Virol 2010 : These results demonstrate that MHV is recognized by both RIG-I and MDA5 and induces IFN-alpha/beta through the activation of the IRF-3 signaling pathway