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GDNF — NEUROD1
Text-mined interactions from Literome
Coulpier et al., J Biol Chem 2002
:
Protein transduction of anti-Tyr ( P ) ( 1062 ) antibodies into cultured cells reduced activation of MAPKs ERK1 and ERK2 and the AKT kinase in
response to
GDNF and diminished GDNF dependent
neuronal differentiation and survival of embryonic sensory neurons from the nodose ganglion
Roussa et al., Neurosci Lett 2004
(Neurodegenerative Diseases) :
GDNF promotes
neuronal differentiation and dopaminergic development of mouse mesencephalic neurospheres
Zhang et al., J Cell Sci 2006
:
Moreover, inhibition of SH2-Bbeta expression by RNA interference caused a significant decrease of
GDNF induced
neuronal differentiation in PC12-GFRalpha1-RET cells
Ledda et al., J Neurosci 2008
:
Downregulation of Lrig1 using small interference RNA knock-down experiments potentiates both
neuronal differentiation and MAPK activation in
response to
GDNF
Murata et al., J Neurosci Res 2008
:
This cell line provides a useful model system for studying the role of a variety of signaling molecules for
GDNF/CNTF induced
neuronal differentiation
Murata et al., Neurosci Lett 2008
:
Autocrine TGF-beta signaling is required for the
GDNF/CNTF induced
neuronal differentiation of adrenal chromaffin tsAM5D cells expressing temperature-sensitive SV40 T-antigen
Mwizerwa et al., Dev Dyn 2011
:
We find that
Gdnf has a pleiotropic effect on colonic ENCCs, promoting proliferation,
inducing neuronal differentiation , and acting as a chemoattractant ... Down regulating
Gdnf similarly
induces premature
neuronal differentiation , but also inhibits ENCC proliferation, leading to distal colorectal aganglionosis with severe proximal hypoganglionosis
Gui et al., Hum Genet 2013
(Hirschsprung Disease) :
Nrg1 inhibited the
Gdnf induced
neuronal differentiation and Gdnf negatively regulated Nrg1 signaling by down regulating the expression of its receptor, ErbB2
Zajzon et al., Neuroreport 2013
:
Concerted interaction of TGF-ß and
GDNF mediates
neuronal differentiation ... In this study, we investigate the role of TGF-ß in
GDNF induced
neuronal differentiation ... On the basis of morphological as well as immunocytological data, we finally show that
GDNF mediated
neuronal differentiation is intensified when GDNF and TGF-ß act in concert