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MAX — MYCN

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: MYCN → Complex of MAX-MYCN (directlyIncreases, MAX/MYCN Activity)
  Evidence: Because MYC proteins function primarily as transcription factors, the consequences of these alterations result in the deregulation of MYC target genes and subsequent effects on cell behavior and in the inability to down-regulate MYC expression to levels sufficiently low for a cell to exit the cell cycle and enter a quiescent state or to differentiate in response to appropriate signals. MYC is a member of the MYC/MAX/MAD network of the basic region/helix-loop-helix/leucine zipper (bHLHZ) domain t...
• WikiPathways Pathways Affected in Adenoid Cystic Carcinoma: MYC/MYCN → MAX (activation)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: MYCN — MAX (physical association, affinity chromatography technology) Amente et al., FEBS Lett 2007*
• IRef Biogrid Interaction: MYCN — MAX (direct interaction, pull down) Blackwood et al., Science 1991*
• IRef Biogrid Interaction: MYCN — MAX (direct interaction, pull down) FitzGerald et al., Oncogene 1999*
• IRef Biogrid Interaction: MYCN — MAX (physical association, affinity chromatography technology) Kim et al., Cell 2010
• IRef Hprd Interaction: MAX — MYCN (in vitro) FitzGerald et al., Oncogene 1999*, Bannasch et al., Oncogene 1999*
• IRef Hprd Interaction: MAX — MYCN (two hybrid) FitzGerald et al., Oncogene 1999*, Bannasch et al., Oncogene 1999*
• IRef Intact Interaction: Complex of MAX-AURKA-MYCN (association, anti bait coimmunoprecipitation) Brockmann et al., Cancer Cell 2013*
• IRef Intact Interaction: MAX — MYCN (physical association, two hybrid) Bannasch et al., Oncogene 1999*
• IRef Intact Interaction: MAX — MYCN (physical association, beta galactosidase complementation) Bannasch et al., Oncogene 1999*
• IRef Intact Interaction: MAX — MYCN (physical association, proximity ligation assay) Brockmann et al., Cancer Cell 2013*
• IRef Ophid Interaction: MAX — MYCN (aggregation, interologs mapping) Brown et al., Bioinformatics 2005