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CDKN1A — TBX2

Text-mined interactions from Literome

Prince et al., Cancer Res 2004 : Here, using a combination of in vitro DNA binding, transfection, and chromatin immunoprecipitation assays, we show that Tbx2 can bind and repress the p21 promoter in vitro and in vivo
Vance et al., Cancer Res 2005 (Melanoma...) : Strikingly, expression of an inducible dominant negative Tbx2 ( dnTbx2 ) leads to displacement of histone deacetylase 1, up-regulation of p21 ( Cip1 ) expression, and the induction of replicative senescence in CDKN2A-null B16 melanoma cells
Hoogaars et al., Pigment Cell Melanoma Res 2008 : In melanoma, the TBX2 gene is frequently amplified and inhibition of Tbx2 function leads to senescence and up-regulation of p21 ( CIP ), a Tbx2 target gene
Lüdtke et al., PLoS Genet 2013 : We conclude that Tbx2 mediated regulation of Cdkn1a and Cdkn1b represents a crucial node in the network integrating patterning information and cell cycle regulation that underlies growth, differentiation, and branching morphogenesis of this organ