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CDKN1A — SRC

Text-mined interactions from Literome

Geijsen et al., Blood 1999 : Furthermore, fMLP induced p21rac activation was not inhibited by broad tyrosine kinase inhibitors or specific inhibitors of ERK, p38 mitogen activated protein kinase, Src , or phosphatidylinositol 3-kinases
Chen et al., Genes Dev 2000 : Exogenous/ectopic expression studies with GRIP-1 sense and antisense vectors in myogenic C2C12 cells demonstrated that this SRC is necessary for ( 1 ) induction/activation of myogenin, MEF-2, and the crucial cell cycle regulator, p21 , and ( 2 ) contractile protein expression and myotube formation
Moiseeva et al., Carcinogenesis 2007 (Breast Neoplasms) : In MCF7 and MDA-MB-231 cells, I3C modulated expression of cell cycle related proteins, p21Cip1, p27Kip1, cyclin E, cyclin D1 and CDK6, with upregulation of p21Cip1 and cyclin E being dependent on Src
Cao et al., Am J Respir Cell Mol Biol 2010 : Using chromatin immunoprecipitation assays and expression of a dominant negative Stat3 mutant, we show that activation of Stat3 and its binding to the p21 promoter are required for DEP induced expression of p21, suggesting that Stat3 plays an essential role in the induction of p21 by DEP. Additional experiments demonstrated that activation of p21 gene expression is dependent on the activation of epidermal growth factor receptor and Src kinase activities
Hawthorne et al., Mol Cancer Res 2009 (Breast Neoplasms) : ErbB2 mediated Src and signal transducer and activator of transcription 3 activation leads to transcriptional up-regulation of p21Cip1 and chemoresistance in breast cancer cells
Tseng et al., Arch Toxicol 2012 : In addition, overexpression of c-Src as well as treatment with ATO could stimulate EGFR-Y845/ERK phosphorylation, p21 expression, and cellular arrest/apoptosis, which could be attenuated by pretreatment with apocynin or knockdown of p67(phox)
Yajima et al., J Dermatol Sci 2012 (Melanoma) : Proliferation of GNG2 overexpressed SK-Mel28 human malignant melanoma cells was suppressed with decreased c-SRC and AKT activities and increased p21 ( Cip/WAF1 ) expression level in vitro