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AKT3 — NOS2
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Hisamoto et al., J Biol Chem 2001
:
Estrogen induces the
Akt dependent activation of endothelial
nitric-oxide synthase in vascular endothelial cells
Hisamoto et al., J Biol Chem 2001
:
Induction of endothelial
nitric-oxide synthase phosphorylation by the raloxifene analog LY117018 is differentially
mediated by
Akt and extracellular signal regulated protein kinase in vascular endothelial cells
Hurt et al., Proc Natl Acad Sci U S A 2002
:
Akt dependent phosphorylation of endothelial
nitric-oxide synthase mediates penile erection
Haynes et al., J Biol Chem 2003
:
Src kinase mediates phosphatidylinositol
3-kinase/Akt dependent rapid endothelial
nitric-oxide synthase activation by estrogen
Park et al., J Immunol 2003
:
Akt as a mediator of secretory phospholipase A2 receptor
involved inducible
nitric oxide synthase expression
Barsacchi et al., Mol Pharmacol 2003
:
Activation of endothelial
nitric-oxide synthase by tumor necrosis factor-alpha : a novel pathway
involving sequential activation of neutral sphingomyelinase, phosphatidylinositol-3 ' kinase, and
Akt
Gobeil et al., J Biol Chem 2003
:
Moreover, LPA induced increases in Ca2+ transients and/or
iNOS expression in highly purified rat liver nuclei were
prevented by pertussis toxin, phosphoinositide
3-kinase/Akt inhibitor wortmannin and Ca2+ chelator and channel blockers EGTA and SK & F96365, respectively
Smith et al., Biochem Soc Trans 2003
:
Vascular endothelial dysfunction in aging : loss of
Akt dependent endothelial
nitric oxide synthase phosphorylation and partial restoration by ( R ) -alpha-lipoic acid
Hattori et al., Eur J Pharmacol 2003
:
A pharmacological inhibitor of the phosphoinositide 3-kinase (PI3K)-Akt pathway, 2- ( 4-morpholinyl ) -8-phenyl-4H-1-benzopyran-4-one ( LY294002 ), inhibited phosphorylation of
Akt and suppressed activation of NF-kappa B by attenuating the phosphorylation and degradation of I kappa B. LY294002 thereby
inhibited LPS/IFN induced
iNOS expression and NO production
Iaccarino et al., Circulation 2004
(Hypertension) :
It was recently reported that
AKT phosphorylates and
activates endothelial
nitric oxide synthase and that impaired kinase activity may be involved in endothelial dysfunction
Florian et al., Steroids 2004
:
Estrogen induced changes in
Akt dependent activation of endothelial
nitric oxide synthase and vasodilation
Kao et al., Immunology 2005
:
In this study, we further investigated the
roles of tyrosine kinase, phosphatidylinositiol 3-kinase
(PI3K)/Akt , and p38 mitogen activated protein kinase ( MAPK ) in LTA induced
iNOS expression and NO release in RAW 264.7 macrophages
Sun et al., Toxicol Appl Pharmacol 2006
:
Serine 1179 phosphorylation of endothelial
nitric oxide synthase caused by 2,4,6-trinitrotoluene through
PI3K/Akt signaling in endothelial cells
Lee et al., Am J Physiol Cell Physiol 2006
:
In conclusion, we demonstrated here that insulin induced VSMC relaxation is dependent on
Akt activation via
iNOS , cGK1alpha, and MBP activation, as well as the decreased phosphorylations of MYPT1 and MLC20 and decreased ROKalpha activity
Penna et al., J Cardiovasc Med (Hagerstown) 2006
:
They also produce a transient dilator effect via the activation of endothelial
nitric oxide synthase mediated by protein kinase
B/Akt
Pan et al., Biochem Pharmacol 2006
(Cocarcinogenesis...) :
Taken together, these results show that acacetin down
regulates inflammatory
iNOS and COX-2 gene expression in macrophages by inhibiting the activation of NF kappa B by interfering with the activation
PI3K/Akt/IKK and MAPK, suggesting that acacetin is a functionally novel agent capable of preventing inflammation associated tumorigenesis
Zecchin et al., Diabetes 2007
(Obesity) :
In addition, ACh induces JAK2/IRS-1 and IRS-1/phosphatidylinositol (PI) 3-kinase associations, downstream
activation of
Akt/protein kinase B, endothelial
cell-nitric oxide synthase ( eNOS ), and extracellular signal regulated kinase ( ERK ) -1/2
Chung et al., Carcinogenesis 2007
(Acute Disease...) :
Taken together, the present study demonstrates that xanthorrhizol not only delays or inhibits tumor formation, but also reverses the carcinogenic process at pre-malignant stages by reducing the protein levels of ODC,
iNOS and COX-2
regulated by the NF-kappaB, mitogen activated protein kinases and/or
Akt
Blanes et al., J Biol Chem 2007
:
Phosphorylation of tyrosine 801 of vascular endothelial growth factor receptor-2 is necessary for
Akt dependent endothelial
nitric-oxide synthase activation and nitric oxide release from endothelial cells
Kim et al., J Med Food 2007
:
Taken together, these experiments demonstrated that IOE70 inhibition of LPS induced expression of
iNOS and COX-2 protein is
mediated by
Akt and JNK
Grossini et al., Endocrinology 2008
:
In porcine aortic endothelial cells, genistein
induced the phosphorylation of endothelial
nitric oxide synthase and NO production through ERK 1/2,
Akt , and p38 MAPK pathways, which was prevented by the concomitant treatment by butoxamine and fulvestrant
Savard et al., J Cell Physiol 2008
:
In isolated nuclei, BK elicited activation/phosphorylation of
Akt , acetylation of histone H3 and ensuing pro-inflammatory
iNOS gene
induction as determined by Western blot and RT-PCR
Pan et al., J Agric Food Chem 2008
:
Taken together, these results show that pterostilbene down
regulates inflammatory
iNOS and COX-2 gene expression in macrophages by inhibiting the activation of NFkappaB by interfering with the activation of
PI3K/Akt/IKK and MAPK
Drouin et al., Stroke 2009
:
In healthy C57Bl/6 mouse cerebral arteries,
Akt dependent activation of endothelial
nitric oxide synthase derived H ( 2 ) O ( 2 ) mediates flow dependent dilation
Csibi et al., PloS one 2010
:
Inhibition of
nitric oxide synthase and NAD ( P ) Hoxidase and scavenging of free radicals with myricetin
restored insulin stimulated
Akt phosphorylation and GLUT4 translocation in the presence of Ang II
Lin et al., Int Immunopharmacol 2010
:
On the other hand, PGN induced
iNOS and COX-2 up-regulation were
attenuated by PI3-kinase inhibitors ( LY294002 and wortmannin ), and an
AKT inhibitor
Zhang et al., Biochim Biophys Acta 2011
:
We hypothesized that
Akt mediates the effect of cAMP on hepatocyte
iNOS expression
Chen et al., Life Sci 2010
:
Calcium- and phosphatidylinositol
3-kinase/Akt dependent activation of endothelial
nitric oxide synthase by apigenin
Pellegrin et al., Can J Physiol Pharmacol 2011
:
Long-term swimming exercise does not modulate the
Akt dependent endothelial
nitric oxide synthase phosphorylation in healthy mice
Conrad et al., Semin Nephrol 2011
(Pre-Eclampsia) :
Newly emerging data support the role of Ga ( i/o ) protein coupling to phosphatidylinositol-3
kinase/Akt ( protein kinase B ) -dependent phosphorylation and
activation of endothelial
nitric oxide synthase in the rapid vasodilatory responses of relaxin
Wu et al., Neurosurgery 2011
(Brain Injuries) :
Akt dependent endothelial
nitric oxide synthase phosphorylation was also induced by simvastatin in vivo and in vitro
Chern et al., Planta Med 2011
(Cerebral Infarction...) :
Andrographolide inhibits
PI3K/AKT dependent NOX2 and
iNOS expression protecting mice against hypoxia/ischemia induced oxidative brain injury
Wang et al., J Cell Physiol 2011
:
Taken together, these results suggested that in astrocytes, activation of NF-?B by ET ( B ) -dependent c-Src,
PI3K/Akt , and p42/p44 MAPK signalings is
necessary for ET-1 induced
iNOS gene up-regulation
Harbrecht et al., Am J Physiol Gastrointest Liver Physiol 2012
(MAP Kinase Signaling System) :
Inhibition of
Akt signaling with LY294002 or a dominant negative Akt plasmid
increased cytokine stimulated nitrite production and
iNOS protein expression and blocked the inhibitory effects of insulin ... NF-?B induces
iNOS expression and can be
regulated by
Akt , but insulin had no effect on cytokine mediated I?Ba levels or NF-?B p65 translocation
Li et al., J Vasc Surg 2012
(Carotid Stenosis...) :
Repetitive progressive thermal preconditioning hinders thrombosis by reinforcing phosphatidylinositol
3-kinase/Akt dependent heat-shock protein/endothelial
nitric oxide synthase signaling
Hong et al., J Agric Food Chem 2012
(Hypertension) :
Panax ginseng extract rich in ginsenoside protopanaxatriol attenuates blood pressure elevation in spontaneously hypertensive rats by affecting the
Akt dependent phosphorylation of endothelial
nitric oxide synthase
Merighi et al., Pharmacol Res 2012
:
We found that exogenous application of H ( 2 ) S ( NaHS and GYY4137 as H(2)S donors ) significantly enhances NO through increase of
iNOS , in a manner
Akt dependent
Bhowmick et al., Free Radic Biol Med 2013
(Adenocarcinoma...) :
Thus, a link between upstream
Akt activation and
iNOS induction was apparent
Bolduc et al., Am J Physiol Heart Circ Physiol 2013
:
First, exercise increases blood flow locally and increases shear stress temporarily, a known stimulus for endothelial cell maintenance of
Akt dependent expression of endothelial
nitric oxide synthase , nitric oxide generation, and the expression of antioxidant defenses