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SOD1 — TNF
Text-mined interactions from Literome
Yamashita et al., J Exp Med 1999
(Myocardial Infarction...) :
The production of reactive oxygen species and endogenous
TNF-alpha and IL-1beta induced by exercise
leads to the activation of
Mn-SOD , which plays major roles in the acquisition of biphasic cardioprotection against ischemia/reperfusion injury in rats
Xu et al., DNA Cell Biol 1999
:
An intronic NF-kappaB element is essential for
induction of the human manganese
superoxide dismutase gene by
tumor necrosis factor-alpha and interleukin-1beta
Maehara et al., J Cell Biochem 2000
:
A NF-kappaB p65 subunit is indispensable for activating manganese
superoxide : dismutase gene transcription
mediated by
tumor necrosis factor-alpha ... Expression of the manganese
superoxide dismutase ( Mn-SOD ) is
induced by
tumor necrosis factor-alpha (TNF-alpha) , interleukin-1 (IL-1), and lipopolysaccharide (LPS) ... This report describes the minimal promoter region of the Mn-SOD gene and investigates the cis acting elements and trans acting factors responsible for
TNF-alpha induced
Mn-SOD gene expression ... These results show that a NF-kappaB p65 subunit is mainly involved in the molecular mechanisms controlling
TNF-alpha mediated
Mn-SOD gene transcription
Liu et al., Free Radic Biol Med 2000
(Carcinoma, Squamous Cell...) :
Oxygen free radicals
mediate the induction of manganese
superoxide dismutase gene expression by
TNF-alpha
Strålin et al., Atherosclerosis 2000
:
The
Mn-SOD activity was strongly
up-regulated by
TNF-alpha and IL-1alpha and moderately by IFN-gamma
Yamashita et al., Br J Pharmacol 2000
(Myocardial Reperfusion Injury...) :
We conclude that the induction and activation of
Mn-SOD ,
mediated by
TNF-alpha and IL-1beta after IP, plays an important role in the acquisition of late-phase cardioprotection against ischaemia/reperfusion injury in rats
Shibuya-Fujiwara et al., Life Sci 2001
:
Liposome encapsulated
superoxide dismutase suppresses liposome mediated augmentation of
TNF-alpha production from peripheral blood leucocytes
Karube-Harada et al., Mol Hum Reprod 2001
:
The present study was undertaken to investigate the
effect of
tumour necrosis factor-alpha (TNFalpha) on
superoxide dismutase ( SOD ) expression in human endometrial stromal cells ( ESC ) and to determine whether there is a difference in responsiveness to TNFalpha between ESC and decidualized ESC ...
TNFalpha increased manganese-SOD ( Mn-SOD ) mRNA level and
Mn-SOD activity in a dose dependent manner in ESC ...
TNFalpha had no effect on
copper-zinc-SOD ( Cu, Zn-SOD ) expression in either type of cell ... Incubation of ESC with actinomycin D, an RNA synthesis inhibitor, blocked
TNFalpha induced
Mn-SOD mRNA expression, but cycloheximide, a protein synthesis inhibitor, had no effect ... H7, an inhibitor of protein kinase C ( PKC ), also inhibited
TNFalpha stimulated
Mn-SOD mRNA expression in both types of cells ... These findings suggest that
TNFalpha induced
Mn-SOD expression is regulated at the transcription level and mediated by PKC dependent phosphorylation and that de-novo protein synthesis is not required for the TNFalpha effect ... In summary,
TNFalpha induces
Mn-SOD expression in human ESC
Wang et al., Chin Med J (Engl) 2002
(Shock, Septic) :
It enhanced plasma
SOD activity [ ( 1037.2 +/- 112.8 ) NU/L vs LPS + saline ( 615.4 +/- 92.6 ) NU/L, P < 0.01 ], reduced the MDA content [ ( 5.2 +/- 1.1 ) micromol/L vs. LPS + saline ( 9.8 +/- 1.5 ) micromol/L, P < 0.01 ], and inhibited
TNF(alpha) induced [ Ca ( 2+ ) ] ( i ) elevation
Sugino et al., J Clin Endocrinol Metab 2002
:
Nuclear factor-kappa B is required for
tumor necrosis factor-alpha induced manganese
superoxide dismutase expression in human endometrial stromal cells ... We recently found that manganese
superoxide dismutase ( Mn-SOD ) is
up-regulated by
TNF alpha at the transcription level in human endometrial stromal cells ( ESC ) and that TNF alpha induced Mn-SOD expression is mediated by protein kinase C ( PKC ) -dependent phosphorylation ...
TNF alpha and TPA significantly
increased Mn-SOD activities and
Mn-SOD mRNA levels, and those effects were completely inhibited by MG132 and SN50
Guo et al., J Biol Chem 2003
:
Role of the intronic enhancer in
tumor necrosis factor mediated induction of manganous
superoxide dismutase ... Two regulatory regions, the proximal promoter region ( PPR ), which is upstream from the transcription initiation site, and the
TNF-responsive element (TNFRE) , which is inside intron 2, are
responsible for
Mn-SOD expression
Ono et al., Biochem Biophys Res Commun 1992
(Carcinoma, Hepatocellular...) :
Induction of
Mn-superoxide dismutase by
tumor necrosis factor , interleukin-1 and interleukin-6 in human hepatoma cells ...
Effects of
Tumor Necrosis Factor (TNF) , Interleukin-1 (IL-1), Interleukin-6 (IL-6) and Interferon-gamma (IFN-gamma) on the expression of
Mn-superoxide dismutase ( Mn-SOD ) protein were investigated in human hepatoma cells, Hu-H1, which revealed resistance to the cytotoxicity of TNF and IL-1
Pang et al., J Biol Chem 1992
(Carcinoma, Papillary...) :
Tumor necrosis factor-alpha activates nuclear factor kappa B and
induces manganous
superoxide dismutase and phosphodiesterase mRNA in human papillary thyroid carcinoma cells
Heller et al., Cell 1992
:
When transfected with the human p70 TNFR, HeLa p70 die within 24 hr. HeLa p70 cells also show reduced c-fos and manganous
superoxide dismutase induction by
TNF
Tada et al., Hokkaido Igaku Zasshi 1992
(Brain Neoplasms...) :
TNF at a low dose ( 10 U/ml )
stimulated production of prostaglandin E2,
Mn-superoxide dismutase , interleukin (IL)-6 and IL-8 by glioblastoma cells
Chang et al., Biochem Biophys Res Commun 1992
:
Cell killing and
induction of manganous
superoxide dismutase by
tumor necrosis factor-alpha is mediated by lipoxygenase metabolites of arachidonic acid ... Our data reveal that
TNF induction of manganous
superoxide dismutase ( MnSOD ) is also dependent upon lipoxygenase activity
Tarabin et al., Naunyn Schmiedebergs Arch Pharmacol 2004
:
Indeed,
TNFalpha stimulated mRNA accumulation of the anti-apoptotic
superoxide dismutase 2 through NF-kappaB whereas 6-OHDA induced mRNA accumulation of the pro-apoptotic c-myc
Marklund et al., J Biol Chem 1992
:
TNF-alpha , IL-1 alpha, and IFN-gamma
stimulated the
Mn-SOD activity, as previously known, and these responses were reduced by TGF-beta
Suzuki et al., Free Radic Res Commun 1992
(Myocardial Infarction) :
These facts suggest that
TNF-alpha secretion from the infarcted area
resulted in the production of
Mn-SOD and that the induced Mn-SOD was released from myocytes into serum through damaged membranes, resulting in the late elevation
Imoto et al., Diabetes 2006
(Carcinoma, Hepatocellular...) :
Using reduced MitoTracker Red probe, we confirmed that
TNF-alpha increased mitochondrial ROS production, which was suppressed by overexpression of either uncoupling protein-1 (UCP)-1 or manganese
superoxide dismutase ( MnSOD )
Basuroy et al., Am J Physiol Cell Physiol 2006
:
The
TNF-alpha response was
inhibited by
superoxide dismutase and catalase suggesting apoptosis is oxidative stress related
Afonso et al., Free Radic Biol Med 2006
:
A JNK inhibitor antagonized the negative effects of TNF-alpha on SOD1 promoter activity, suggesting that JNK signaling through c-Jun protein activation is critical for the
TNF-alpha dependent
SOD1 repression ... A greater understanding of the mechanisms of
TNF-alpha induced
SOD1 repression could facilitate the design and development of novel therapeutic drugs for inflammatory conditions
Son et al., American journal of physiology. Renal physiology 2008
(Disease Models, Animal...) :
Our in vitro studies utilizing cultured tubular cells revealed a
role of
TNF-alpha in downregulation of
Cu/Zn-SOD
Xiao et al., Wei Sheng Yan Jiu 2008
(Obesity...) :
( 2 ) Serum
SOD and GR activity decreased, and
TNF-alpha level
increased with body mass index ( BMI ) and abdominal fat mass, as shown by linear correlation analysis
Hu et al., J Ethnopharmacol 2008
(Drug-Induced Liver Injury) :
Pretreatment with CGX significantly restored the reduction of catalase activity and glutathione ( GSH ) content, but not
superoxide dismutase ( SOD ) activity, and it
inhibited the CCl ( 4 ) -induced high expression of iNOS and
TNF-alpha in hepatic tissue
Harris et al., J Immunol 1991
:
Mn-SOD is
induced by IFN-gamma and also by
TNF in all four human cell lines examined : HS153 fibroblasts, ACHN renal carcinoma, A549 lung carcinoma, and A375 melanoma
Brauer et al., Neoplasia (New York, N.Y.) 2010
(Neovascularization, Pathologic) :
Short interfering RNA ( siRNA ) -mediated knockdown of one of the photoaffinity labeled proteins,
superoxide dismutase 1 , an ROS scavenger,
resulted in an increase in
tumor necrosis factor-alpha production by RAW 264.7 cells in response to DMXAA compared with negative or positive controls transfected with nontargeting or lamin A/C targeting siRNA molecules, respectively
Chertoff et al., Exp Neurol 2011
(Chronic Disease...) :
Protective effects of low
TNF-a level could be
mediated by TNF-R1, GDNF, and IGF-1 in the SN and
SOD activity in the striatum ( ST )
Zhang et al., World J Gastroenterol 2011
(Reperfusion Injury) :
In group PHC, the tissue DAO and
SOD activity at T2-T6, and IL-10 at T2-T5
increased to higher levels than those in group LIR ( P < 0.05 ) ; however, the levels of MPO, endotoxin, and DAO in the blood at T2-T6, and
TNF-a at T2 and T4 decreased ( P < 0.05 )
Kawaguchi et al., Biochem Biophys Res Commun 1990
(Adenocarcinoma...) :
Stimulation of
Mn-superoxide dismutase expression by
tumor necrosis factor-alpha : quantitative determination of Mn-SOD protein levels in TNF-resistant and sensitive cells by ELISA
Tsan et al., Am J Physiol 1990
:
Molecular basis for
tumor necrosis factor induced increase in pulmonary
superoxide dismutase activities
Zhu et al., Nan Fang Yi Ke Da Xue Xue Bao 2012
(Acute Lung Injury) :
Compared with those in LPS group, IL-1ß, IL-6,
TNF-a and MDA in BALF, W/D, lung injury scores and iNOS mRNA and protein expression were significantly reduced and
SOD in the BALF significantly
increased in LPS+DAS group
Grdina et al., Radiat Res 2013
(Genomic Instability) :
Utilizing these end points, RKO human colon carcinoma and transformed mouse embryo fibroblasts (MEF), wild-type or knockout cells missing TNF receptors 1 and 2 ( TNFR1 ( - ) R2 ( - ) ), and C57BL/6 and TNFR1 ( - ) R2 ( - ) knockout mice, we demonstrate that intact
TNF signaling is
required for induction of elevated manganese
superoxide dismutase ( SOD2 ) activity ( P < 0.001 ) and the subsequent expression of these SOD2 mediated adaptive responses when cells are challenged at a later time with 2 Gy
Kong et al., Lipids in health and disease 2013
:
However, comparing to the model rabbits, levels of
TNF-a , IL-1ß and MDA decreased significantly and serum
SOD activity
increased , gene and protein expressions of E-sel, ICAM-1, VCAM-1 and MCP-1 in aortas decreased significantly with the treatment of kaempferol
Asoh et al., Biochem Biophys Res Commun 1989
(Breast Neoplasms) :
Induction of manganese
superoxide dismutase by
tumor necrosis factor in human breast cancer MCF-7 cell line and its TNF-resistant variant ... TNF induced more mitochondrial manganese SOD ( SODm ) in MCF-7 than in Tnf-1000 whereas there appeared to be no significant
induction of cytosolic copper/zinc
SOD ( SODc ) by
TNF in both MCF-7 and Tnf-1000 cell lines
Wong et al., Science 1988
:
Induction of manganous
superoxide dismutase by
tumor necrosis factor : possible protective mechanism
Das et al., Mol Cell Biochem 1995
(Adenocarcinoma...) :
TNF alpha and IL-1 each can activate NF-kappa B and
induce gene expression of manganese
superoxide dismutase ( MnSOD ), a mitochondrial matrix enzyme which can provide critical protection against hyperoxic lung injury
Perera et al., Arch Biochem Biophys 1995
(Carcinoma, Hepatocellular...) :
Differential
regulation of manganese
superoxide dismutase activity by alcohol and
TNF in human hepatoma cells
Wong et al., Biochim Biophys Acta 1995
:
TNF or LT can specifically and selectively
induce the expression of manganous
superoxide dismutase ( MnSOD )
Nelson et al., J Mol Cell Cardiol 1995
(Myocardial Ischemia...) :
Leukemia inhibitory factor and
tumor necrosis factor induce manganese
superoxide dismutase and protect rabbit hearts from reperfusion injury
Lin et al., Lymphokine Cytokine Res 1993
(Breast Neoplasms) :
Cytotoxicity and manganese
superoxide dismutase induction by
tumor necrosis factor-alpha and ionizing radiation in MCF-7 human breast carcinoma cells
Niwa et al., Am J Pathol 1993
:
Both manganese SOD and copper, zinc
SOD activities were significantly
induced by paraquat, interleukin-1,
tumor necrosis factor , adriamycin, and bleomycin in lymphocytes and neutrophils from asymptomatic non aged adults, whereas neither activity was induced in aged individuals
Nakata et al., Int J Cancer 1993
:
These data suggest that, in vivo, the
TNF alpha and IL-1 alpha produced by cancer cells and other cells may
induce Mn-SOD in vascular endothelial cells as well as other host tissues, resulting in release of a relatively large amount of this protein into the serum
Hirose et al., FASEB J 1993
(Melanoma) :
Interleukin-1 (IL-1) and
tumor necrosis factor (TNF) selectively
induce mitochondrial manganese
superoxide dismutase ( MnSOD ) production in various cell types
Nakata et al., Nihon Sanka Fujinka Gakkai Zasshi 1995
(Neoplasms) :
These data suggest that in vivo the
TNF-alpha produced by cancer cells may
induce Mn-SOD in vascular endothelial cells, resulting in release of a relatively large amount of this protein into the serum
Pietarinen-Runtti et al., Cell Biol Toxicol 1996
:
We compared
induction of manganese
superoxide dismutase ( MnSOD ) by asbestos fibers and
tumor necrosis factor alpha (TNF) using cultured human mesothelial cells
Liu et al., J Formos Med Assoc 1996
(Gingival Hyperplasia) :
To determine whether lipopolysaccharide (LPS) and
tumor necrosis factor-alpha (TNF-alpha) are
involved in the induction of
superoxide dismutase ( SOD ) in gingival tissue, we examined their effect on induction of SOD isozymes in cultured normal ( NGF ) and phenytoin induced hyperplastic ( PHF ) gingival fibroblasts
Polla et al., Free radical research 1996
:
Furthermore,
SOD was
inducible by
TNF alpha in L929 cells, but not in L929.12 cells
Antras-Ferry et al., FEBS Lett 1997
:
IL-1beta and
TNF-alpha both
stimulated specifically
Mn-SOD gene expression in a time dependent manner ...
TNF-alpha rapidly
induced Mn-SOD gene expression while IL-1beta was a strong but slow inducer of this gene ... These results suggest that IL-1beta and
TNF-alpha regulate
Mn-SOD gene transcription by different pathways
Mattson et al., Neurosci Biobehav Rev 1997
(Cerebrovascular Disorders) :
For example : basic fibroblast growth factor suppresses expression of a glutamate receptor protein and induces antioxidant enzymes ;
tumor necrosis factor induces expression of a Ca ( 2+ ) -binding protein and
Mn-superoxide dismutase ; and secreted forms of beta-amyloid precursor protein hyperpolarize neurons by activating K+ channels
Sasaki et al., Photochem Photobiol 1997
:
Interleukin-1 alpha and
TNF-alpha enhanced both the
SOD activity and protein level of Mn SOD, while these cytokines had no effect on Cu-Zn SOD protein levels in cultured human keratinocytes after incubation for 24 h
Shibuya et al., Hepatology 1997
(Liver Diseases...) :
After 24 hours of preservation, superoxide generation was inhibited in the control livers by anti-TNF antiserum, whereas
TNF release was not
inhibited by
superoxide dismutase
Liochev et al., Free Radic Biol Med 1997
:
The manganese containing mitochondrial
superoxide dismutase ( MnSOD ) is
induced by
TNF and protects against the necrotic effect of this cytokine
Kettritz et al., J Am Soc Nephrol 1997
:
No upregulation of endogenous manganese
superoxide dismutase mRNA expression was observed in
response to
TNF alpha as measured by reverse transcription PCR
Arai et al., Biochem J 1998
(Second Messenger Systems) :
TNF-alpha upregulation of endothelial-cell ICAM-1 expression was
inhibited by the cell-permeable antioxidants, or by the adenovirus mediated intracellular overexpression of Cu,
Zn-superoxide dismutase , but not by the exogenous ( extracellular ) administration of the cell-impermeable antioxidants, superoxide dismutase and/or catalase
Takahashi et al., J Dermatol Sci 1998
:
Using SV40 transformed human keratinocytes ( SVHK cells ), we investigated the
effects of anti-Fas antibody and
TNF-alpha on the
SOD activity ... The
induction of IFN-gamma dependent
Mn-SOD activity by anti-Fas antibody or
TNF-alpha was concentration dependent ; the maximal effect was observed at 1-10 micrograms/ml and 5-10 ng/ml, respectively ... These results indicate that the stimulation of Fas antigen or
TNF receptor
increases Mn-SOD activity of SVHK cells in the presence of IFN-gamma and that TPA augments the process through the activation of protein kinase C