◀ Back to TNF
KDR — TNF
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
Complex of KDR-PTPN11
→
TNF
(increases)
Evidence: TNF- inhibits VEGF signaling by recruiting SHP-2 to the VEGFR2 in ECs (42).
Text-mined interactions from Literome
Zhang et al., J Biol Chem 2003
:
In
response to
TNF , Etk and
VEGFR2 form a complex resulting in a reciprocal activation between the two kinases
Sugano et al., Circulation 2004
(Ischemia) :
In a rat model of hindlimb ischemia, VEGF increased but activation of
KDR/flk-1 was
suppressed , possibly by
TNF-alpha , which might impair angiogenesis
Yang et al., J Surg Res 2004
:
TNF-alpha significantly
reduced protein levels of
VEGFR-2 , VEGFR-3, and NRP-1 by 59, 35, and 22 %, respectively
Zhao et al., Br J Ophthalmol 2007
(Diabetic Retinopathy) :
TNFalpha up
regulated both VEGF-C and vascular endothelial growth factor receptor-2 (
VEGFR)-2 expression in endothelial cells in a dose dependent manner, but had no effect on VEGFR-3
Galvão et al., Biol Reprod 2012
:
In early CL cells,
TNF increased angiogenic activity ( bovine aortic endothelial cell viability ) and VEGF and
VEGFR2 mRNA levels and decreased CD36 ( real-time PCR relative quantification )
Chan et al., Arterioscler Thromb Vasc Biol 2012
(Diabetes Mellitus...) :
In mice with diabetes mellitus, excessive
tumor necrosis factor-a induced miR-200b blunting proangiogenic functions of GATA2 and
VEGFR2