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FOXO3 — SOD2
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Abid et al., J Biol Chem 2004
:
Overexpression of a constitutively active ( phosphorylation-resistant ) form of
FKHRL1 ( TMFKHRL1 )
resulted in increased
Mn-SOD expression, suggesting that the negative effect of PI3K-Akt involves attenuation of forkhead activity
Fallarino et al., J Exp Med 2004
:
IFN-gamma-driven expression of tryptophan catabolism by CTLA-4-immunoglobulin is made possible through the concomitant activation of the
Forkhead Box class O ( FOXO ) transcription factor FOXO3a,
induction of the
superoxide dismutase gene, and prevention of peroxynitrite formation
Kato et al., J Am Soc Nephrol 2006
(Diabetic Nephropathies) :
This FoxO3a inactivation was accompanied by significant decreases in the expression of two key FoxO3a target genes, the proapoptotic Bim and antioxidant manganese
superoxide dismutase in MC. TGF-beta treatment triggered the nuclear exclusion of FoxO3a, significantly
inhibited FoxO3a transcriptional activity, and markedly protected MC from apoptosis
Jeong et al., Cell Mol Neurobiol 2011
:
The depletion of
Foxo3a led to a marked reduction of Prx III and a compensatory enhancement of mitochondrial
superoxide dismutase ( Mn-SOD ) in PC12 cells ... The results of this study suggest that
Foxo3a mediates the neuronal levels of expression of Prx III and the levels of expression of
Mn-SOD in mitochondria
Liu et al., Hepatology 2012
(Disease Models, Animal...) :
In WT livers, ß-catenin was found to coprecipitate with
forkhead box O3 , the upstream
regulator of
SOD2