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NOTCH2 — RRAS

Text-mined interactions from Literome

Hodkinson et al., J Biol Chem 2007 : Membrane bound Notch mutants that are inefficiently cleaved or intracellular Notch mutants lacking the ankyrin repeat sequence do not activate R-Ras or integrins
Karsan et al., Science signaling 2008 (Cardiovascular Diseases...) : It is proposed that Notch dependent activation of R-Ras reverses H-Ras mediated suppression of integrin affinity ... Activation of R-Ras by Notch may be triggered by a noncanonical CSL ( CBF1 or RBP-Jkappa in vertebrates, Suppressor of Hairless in Drosophila, Lag-1 in Caenorhabditis elegans ) -independent pathway