Yadav et al., J Immunol 2006
(Mycobacterium Infections) :
Macrophage 's proinflammatory response to a mycobacterial infection is dependent on sphingosine kinase mediated activation of phosphatidylinositol phospholipase C, protein kinase C, ERK1/2 , and phosphatidylinositol 3-kinase
Cheon et al., Biochem Biophys Res Commun 2008
:
As a result, inhibition of SPHK by SKI blocked phosphorylation of p38 MAPK , showing that SPHK activation by IL-18 is an upstream signal of p38 MAPK activation