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PIK3R1 — SLC2A1
Text-mined interactions from Literome
Barata et al., J Exp Med 2004
(Precursor Cell Lymphoblastic Leukemia-Lymphoma) :
PI3K signaling was also
required for cell size increase, up-regulation of CD71, expression of the glucose transporter
Glut1 , uptake of glucose, and maintenance of mitochondrial integrity
Barata et al., Leukemia & lymphoma 2005
(Leukemia-Lymphoma, Adult T-Cell) :
PI3K signaling is also
required for the expression of the glucose transporter
Glut1 , uptake of glucose, activation of the metabolic machinery, increase in cell size, and maintenance of mitochondrial integrity
Swainson et al., Blood 2007
:
Glut-1 is directly
regulated by
PI3K and, indeed, inhibiting PI3K activity abrogates IL-7 induced proliferation
Shang et al., J Endocrinol 2008
:
Rb(1) induced glucose uptake as well as
GLUT1 and GLUT4 translocations was
inhibited by the
PI3K inhibitor
Melstrom et al., Pancreas 2008
(Pancreatic Neoplasms) :
In addition, the inhibitory
effects of apigenin and the
PI3K inhibitors on
GLUT-1 are similar, indicating that the PI3K/Akt pathway is involved in mediating apigenin 's effects on downstream targets such as GLUT-1