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EDN1 — PXN

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: PXN → EDN1 (increases) Shi-Wen et al., Mol Biol Cell 2004*
  Evidence: Figure 8. Endothelin induces {alpha}-SMA, paxillin, moesin, and ezrin expression; SSc fibroblasts overexpress {alpha}-SMA, paxillin, moesin, and ezrin in a manner that is dependent on endogenous ET-1 signaling. Normal and SSc fibroblasts were treated with and without 100 nM ET-1 (24 h) as indicated in the presence or absence of bosentan or wortmannin. Cell layers were harvested, and equal amounts of protein were subjected to SDS-PAGE and Western blot analysis with anti-{alpha}-SMA, anti-paxillin...

Text-mined interactions from Literome

Morishita et al., Neurosci Res 2007 : In contrast, endothelin increased tyrosine phosphorylation of focal adhesion kinase ( FAK ) and paxillin in an integrin ligand dependent manner ... A PKC inhibitor and down-regulation of PKC prevented endothelin induced phosphorylation of paxillin and ERK
Zachary et al., J Biol Chem 1993 : Vasopressin and endothelin also stimulated paxillin tyrosine phosphorylation
Rankin et al., J Biol Chem 1996 : In contrast, tyrosine phosphorylation of p125FAK and paxillin in response to bombesin, endothelin , and phorbol 12,13-dibutyrate was not inhibited by wortmannin in these cells