◀ Back to IL1B

IL1B — JAK2

Pathways - manually collected, often from reviews:

• NCI Pathway Database IL12-mediated signaling events: IL1 beta (IL1B) → IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2) (modification, activates)
  Yamamoto et al., Biochem Biophys Res Commun 1999, Bacon et al., J Exp Med 1995, Hunter et al., J Immunol 1995, Presky et al., Proc Natl Acad Sci U S A 1996, Zou et al., J Biol Chem 1997, Gollob et al., Blood 1998
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database IL12-mediated signaling events: IL1 beta (IL1B) → IL12Rbeta2/JAK2 complex (IL12RB2-JAK2) (modification, activates)
  Yamamoto et al., Biochem Biophys Res Commun 1999, Bacon et al., J Exp Med 1995, Hunter et al., J Immunol 1995, Presky et al., Proc Natl Acad Sci U S A 1996, Zou et al., J Biol Chem 1997, Gollob et al., Blood 1998
  Evidence: mutant phenotype, assay, physical interaction, other species

Text-mined interactions from Literome

Finder et al., Am J Physiol Lung Cell Mol Physiol 2001 (MAP Kinase Signaling System) : IL-1beta activated the three mitogen activated protein kinase ( extracellular signal regulated kinases 1 and 2, c-Jun NH2-terminal kinase/stress activated protein kinase, and p38 ) and the Janus kinase ( JAK ) -signal transducer and activator of transcription pathways
Okugawa et al., Am J Physiol Cell Physiol 2003 (Gram-Negative Bacterial Infections) : Finally, we show that JAK2 is involved in the production of IL-1beta and IL-6
Yu et al., Biochem Pharmacol 2006 (Disease Models, Animal...) : In the present study, we investigated whether the activation of Jak/Stat signaling mediates IL-1beta expression in pancreatic acinar AR42J cells stimulated with cerulein in vitro as well as the rats with cerulein pancreatitis in vivo using AG490, the Jak2 inhibitor
Liu et al., Endocrinology 2006 : Although there was no effect of IL-1beta on the phosphorylation of ELK, Janus kinase 2 , or signal transducers and activators of transcription ( STAT ) 1, IL-1beta significantly increased tyrosine-phosphorylation of STAT3, an effect attenuated by PD98059
Honsho et al., Circ Res 2009 (Endomyocardial Fibrosis...) : Promoter analysis showed that stretch mediated IL-1beta activates JAK/STAT to transcriptionally regulate the IGF-1 gene