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IL15 — IL1B
Text-mined interactions from Literome
Ribbens et al., Immunology 2000
:
Under these conditions
IL-1beta production was induced almost exclusively by Th1 cells and was
dependent on the presence and dose of IL-2 or
IL-15 , and on cell-cell contact, as demonstrated by double-chamber cultures ... Preferential expression on Th1 cells of CD11b correlated with their capacity to induce
IL-1beta production by THP-1 cells in the
presence of IL-2 or
IL-15 , but anti-CD11b monoclonal antibody could not inhibit this activity
Burger et al., Arthritis Res 2000
(Arthritis, Rheumatoid) :
IL-1beta and TNF-alpha also
induce IL-15 in fibroblast like synoviocytes, which induces the production of IL-17 which in turn potentiates IL-1beta and TNF-alpha production in monocyte-macrophages
Lottaz et al., J Invest Dermatol 2001
:
In interleukin-1beta transfected human dermal fibroblasts,
interleukin-8 was
induced through an autocrine activity of
interleukin-1beta
Jablonska et al., Cytokine 2001
(Carcinoma, Squamous Cell...) :
Effect of
IL-15 on the secretion of
IL-1beta , IL-1Ra and sIL-1RII by PMN from cancer patients
Cho et al., Arthritis Rheum 2002
(Arthritis, Rheumatoid) :
In a semiquantitative PCR, CSA increased IL-10 mRNA expression but strongly suppressed
IL-1beta induced
IL-15 and TNFalpha mRNA expression, indicating that the production of these cytokines by CSA was regulated at the transcriptional level
Sugiura et al., Int Immunol 2002
(Dermatomyositis...) :
Myoblasts constitutively produced a low level of
IL-15 and the production was
augmented by stimulation with IFN-gamma, IL-1alpha,
IL-1beta , TNF-alpha or lipopolysaccharide (LPS) in a dose dependent manner
Cardozo et al., Diabetologia 2003
:
IL-1beta and IFN-gamma
induce the expression of diverse chemokines and
IL-15 in human and rat pancreatic islet cells, and in islets from pre-diabetic NOD mice
Hassanain et al., Neuroscience 2003
:
In particular,
interleukin-1beta in the medial hypothalamus potentiates defensive rage behavior elicited from the periaqueductal gray in the cat, and the potentiating effects of
interleukin-1beta on this form of emotional behavior are
mediated via a 5-HT2 receptor mechanism
Fujiwara et al., Cancer Res 1992
:
Specific inhibition of
interleukin 1 beta gene expression by an antisense oligonucleotide : obligatory
role of
interleukin 1 in the generation of lymphokine activated killer cells
Bouchard et al., J Leukoc Biol 2004
:
We quantified IL-1Ra, IL-1alpha, and IL-1beta concentrations by enzyme linked immunosorbent assay in intracellular and extracellular fractions from IL-15 induced neutrophils and found that
IL-15 does not
increase IL-1alpha or
IL-1beta production but induces IL-1Ra release
Luz et al., Neuropeptides 2006
(Dehydration...) :
These results suggest that the central
activation of
interleukin-1 receptors by
IL-1beta is able to impair the thirst inducing mechanisms triggered by the physiological stimuli represented by dehydration, hyperosmolarity and hypovolemia
Bernardino et al., J Neurochem 2008
(Encephalitis...) :
Potentiation of AMPA toxicity was prevented when
IL-1beta production or its receptor signaling were
blocked by an inhibitor of
interleukin-converting-enzyme or IL-1 receptor antagonist during application of LPS + ATP
Haber et al., Exp Parasitol 2009
(Hyperalgesia...) :
Leishmania major
: interleukin-13 increases the infection induced hyperalgesia and the levels of
interleukin-1beta and interleukin-12 in rats
Elias et al., Chest 1990
(Pneumonia...) :
To understand the processes regulating inflammation and fibrosis in the human lung, we characterized the
effects of recombinant
interleukin-1 , tumor necrosis factor, and gamma interferon on fibroblast proliferation, collagen production, interleukin-1-alpha production,
interleukin-1-beta production, and interleukin-6 production
Rodriguez-Cimadevilla et al., Blood 1990
(Leukemia, Myeloid, Acute) :
Coordinate secretion of
interleukin-1 beta and granulocyte-macrophage colony stimulating factor by the blast cells of acute myeloblastic leukemia :
role of
interleukin-1 as an endogenous inducer
Mauviel et al., Biochem Biophys Res Commun 1988
:
The ability of the two forms of
interleukin-1 , IL-1 alpha and IL-1 beta, to
induce IL-1 beta gene expression in human skin fibroblasts was studied in vitro, using Northern blot hybridization
Yoza et al., J Biol Chem 1996
:
In human monocytes,
interleukin 1beta protein production and steady state mRNA levels are increased in response to lipopolysaccharide, predominantly as a
result of increased transcription of the
interleukin 1beta gene
Kang et al., Spine (Phila Pa 1976) 1997
(Intervertebral Disc Displacement) :
Normal and herniated human intervertebral disc specimens were cultured to study the
effects of
interleukin-1 beta on the production of nitric oxide,
interleukin-6 , prostaglandin E2, and matrix metalloproteinases ... Normal, control disc specimens significantly increased their production of matrix metalloproteinases, nitric oxide,
interleukin-6 , and prostaglandin E2 in
response to
interleukin-1 beta ... Herniated lumbar and cervical discs, which were spontaneously releasing increased levels of these biochemical agents, further increased their production of nitric oxide,
interleukin-6 , and prostaglandin E2 in
response to
interleukin-1 beta
Kiriyama et al., J Neuroimmunol 1997
(Glioblastoma) :
In human glioblastoma A172 cells,
interleukin-6 (IL-6) production was
induced by
interleukin-1 beta (IL-1 beta) and dibutyryl cyclic AMP