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HLA-DRB1 — SEA

Text-mined interactions from Literome

Pinchuk et al., J Immunol 2007 (Inflammation...) : The SEA induction of the proinflammatory mediators by IMFs resulted from the efficient cross linking of MHC class II molecules because cross linking of class II MHC by biotinylated anti-HLA-DR Abs induced similar cytokine patterns
Tang et al., PloS one 2012 : In this study, we examined the regulatory effect of Schistosoma japonicum soluble egg antigen (SEA) on MHC class II expression in macrophage cell line RAW 264.7 ... Our findings suggest that in RAW 264.7 cells ( 1 ) IFN-? provides a condition for lower concentrations of SEA to attenuate MHC class II expression ; ( 2 ) SEA attenuated IFN-? induced MHC class II expression and the IL-10 and IL-6 production is mediated at least partly by the interaction of SEA with TLR4 ; and ( 3 ) SEA attenuated IFN-? induced MHC class II expression at the transcriptional level