Yarmus et al., Proc Natl Acad Sci U S A 2006
:
Runx3 ( VWRPY- ) also failed to mediate the epigenetic silencing of CD4 gene in CD8 ( + ) T cells, but normally regulated other pan-CD8 ( + ) T cell genes
Hassan et al., Proc Natl Acad Sci U S A 2011
:
The Cd8 enhancer E8 ( I ) and Runx/core binding factor-ß ( CBFß ) complexes were required for the establishment of this regulatory circuit, because E8 ( I ) -, Runx3- , or CBFß-deficient CD8 ( + ) T cells down-regulated CD8a expression during activation