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NOS2 — TP53
Text-mined interactions from Literome
Hsieh et al., Cancer Res 1999
:
Resveratrol increases
nitric oxide synthase ,
induces accumulation of
p53 and p21 ( WAF1/CIP1 ), and suppresses cultured bovine pulmonary artery endothelial cell proliferation by perturbing progression through S and G2
Mortensen et al., J Biol Chem 1999
(Breast Neoplasms) :
Endogenous endothelial cell
nitric-oxide synthase modulates apoptosis in cultured breast cancer cells and is transcriptionally
regulated by
p53
Kang et al., Regul Pept 2001
:
On the other hand, SP slightly induces
p53 and highly
induces Bcl-2,
iNOS expression and NO production
Blanco et al., Neoplasia (New York, N.Y.) 2007
(Chronic Disease...) :
Our results showed DDR pathway activation in preneoplastic lesions, in association with inducible
nitric oxide synthase and
p53 induction
Verma et al., BMC cancer 2009
(Breast Neoplasms) :
Inhibition of
iNOS blocked the induction of
p53
Das et al., Chem Biol Interact 2009
(Carcinoma, Non-Small-Cell Lung) :
Although both compounds are weakly but equally effective inhibitors of
iNOS protein expression and activity, only Se-PBIT significantly
enhanced the levels of
p53 , p38, p27 and p21 protein expression, reduced levels of phospholipase A2 (PLA2) but had no effect on cyclooxygenase-2 (COX-2) protein levels ; such molecular targets are involved in cell growth inhibition, induction of apoptosis and cell cycle regulation
Park et al., Mol Carcinog 2012
(Colonic Neoplasms...) :
HFD feeding increased tumor tissue levels of Ki67, cyclin A, cyclin D1, CDK2, Bcl-xL, and Bcl-2 ; reduced
p53 levels and TUNEL positive apoptotic cells ;
increased the levels of CD45, CD68, CD31, VEGF, P-VEGF receptor-2,
iNOS , and COX-2 as well as hemoglobin content ; and increased the levels of HIF-1a, P-STAT3-Y705, P-STAT3-S727, P-I?B-a, P-p65, p65, P-c-Jun, P-Akt, P-ERK1/2, P-p38, and P-SAPK/JNK
Taylor et al., Biochemistry (Mosc) 1998
(Acute-Phase Reaction...) :
iNOS expression requires the transcription factor NF-kappaB and is
down-regulated by steroids, TGF-beta, the heat shock response,
p53 , and nitric oxide ( NO ) itself