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GRAP2 — MMP1

Text-mined interactions from Literome

Xu et al., Biochem J 2001 : In the present study we demonstrate that p38alpha mitogen activated protein kinase ( p38alpha MAPK ) plays a bi-directional role in the MMP-1 response to contracting floating collagen lattices ( fl-coll ) ... Partial inhibition of p38 MAPK activity resulted in the lowest level of MMP-1 expression, whereas total inhibition of p38 activity led to MMP-1 levels as high as in the absence of inhibitor
Reunanen et al., J Biol Chem 2002 : Inhibition of p38 activity by SB203580 markedly ( by 80-90 % ) inhibited induction of MMP-1 and MMP-3 expression by tumor necrosis factor-alpha, whereas blocking the activation of ERK1/2 by PD98059 had no effect
Lai et al., J Immunol 2003 : Thus, LPS induction of MMP-1 production by monocytes is regulated by both ERK1/2 and p38 , whereas MMP-9 stimulation occurred mainly through the ERK1/2 pathway ... Moreover, p38 regulates MMP-1 mainly through a PGE ( 2 ) -dependent pathway, whereas ERK1/2 mediated MMP-1 and MMP-9 production involves the activation of additional MMP promoter sites through a PGE ( 2 ) -independent mechanism
Utani et al., J Biol Chem 2003 (MAP Kinase Signaling System) : Studies with specific inhibitors of MAPKs showed that p38 MAPK activation was necessary for both IL-1 beta and MMP-1 induction, but Erk activation was required only for MMP-1 induction
Cheung et al., Cancer Res 2006 (Neoplasm Invasiveness...) : In addition, we showed that the c-Jun NH ( 2 ) -terminal kinase, but not extracellular signal regulated kinase 1/2 or p38 mitogen activated protein kinase, signaling pathway was critical for GnRH mediated up-regulation of MMP , cell invasion, and motility
Kunisch et al., Ann Rheum Dis 2007 (Arthritis, Rheumatoid...) : Predominant activation of MAP kinases and pro-destructive/pro-inflammatory features by TNF alpha in early-passage synovial fibroblasts via TNF receptor-1 : failure of p38 inhibition to suppress matrix metalloproteinase-1 in rheumatoid arthritis
Junttila et al., Oncogene 2007 (Carcinoma, Squamous Cell...) : Inhibition of endogenous p38alpha or p38delta activity by adenoviral delivery of corresponding dominant negative p38 isoforms potently reduced MMP-13 and MMP-1 expressions, and suppressed the invasion of HNSCC cells through collagen
Sanka et al., Invest Ophthalmol Vis Sci 2007 : Primary human TM ( HTM ) cells treated with different actin cytoskeleton interfering agents, including cytochalasin D, latrunculin A, ethacrynic acid ( ECA ), a Rho kinase inhibitor ( Y-27632 ), and H-7 ( serine/threonine kinase inhibitor ), were examined for changes in actin cytoskeletal organization by phalloidin staining, MMP-2 activation by gelatin zymography, expression of MT1-MMP by quantitative real-time PCR analysis, levels of tissue inhibitor of metalloproteinases ( TIMP-1 and TIMP-2 ), and activation of p38 mitogen activated protein kinase ( p38 MAPK ) and extracellular signal regulated protein kinase ( ERK ) by immunoblotting
Pillinger et al., J Biol Chem 2007 (Helicobacter Infections...) : MEK inhibitors UO126 and PD98059 inhibited both CagA independent and -dependent MMP-1 secretion, whereas p38 inhibition enhanced MMP-1 secretion and ERK activation, suggesting p38 negative regulation of MMP-1 and ERK
Oner et al., J Clin Endocrinol Metab 2008 (Chorioamnionitis...) : Effects of progestin-p38 MAPK signaling inhibition on cytokine enhanced MMP-1 and MMP-3 expression in term DCs suggest alternative mechanisms to prevent CAM induced PTD
Nakatani et al., Arch Oral Biol 2009 : Effects of specific inhibitors of p38 mitogen activated protein kinase ( MAPK ) activity, MAPK kinase activity and NFkB activity on HAoligo induced MMP-1 expression in HPDL cells were also investigated by real-time PCR and Western blot analyses
Lin et al., International journal of molecular sciences 2013 : BDNF mediated cell motility and MMP-1 up-regulation were attenuated by Trk inhibitor ( K252a ), ASK1 inhibitor ( thioredoxin ), JNK inhibitor ( SP600125 ), and p38 inhibitor ( SB203580 )
Westermarck et al., Matrix Biol 1998 : In addition, expression of kinase-deficient forms of ERK1,2, SAPKbeta, p38 , or JNK/SAPK kinase SEK1 strongly inhibited OA-elicited activation of MMP-1 promoter ... Results of this study show that MMP-1 gene expression in fibroblasts is coordinately regulated by ERK1,2, JNK/SAPK, and p38 MAPKs and suggest an important role for the stress activated MAPKs JNK/SAPK and p38 in the activation of MMP-1 gene expression