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APP — CTNNB1

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: CTNNB1 → APP (decreases, CTNNB1 Activity) Chen et al., Journal of neuroinflammation 2007*
  Evidence: Further, beta-catenin was dramatically increased in hippocampal CA1 pyramidal cells from APP knockout animals.

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: CTNNB1 — APP (direct interaction, pull down) Oláh et al., J Biol Chem 2011

Text-mined interactions from Literome

Chen et al., Apoptosis 2004 (Alzheimer Disease...) : APP induces neuronal apoptosis through APP-BP1 mediated downregulation of beta-catenin
Chen et al., Journal of neuroinflammation 2007 : We demonstrate that APP expression in primary neurons induces beta-catenin phosphorylation at Ser33, Ser37, and Thr41 ( S33/37/T41 ) residues, which is a prerequisite for beta-catenin ubiquitinylation and proteasomal degradation ... APP induced phosphorylation of beta-catenin resulted in the reduction of total beta-catenin levels, suggesting that APP expression promotes beta-catenin degradation ... Acute expression of wild type APP or of familial AD APP mutants in primary neurons downregulated beta-catenin in membrane and cytosolic fractions, and did not appear to affect nuclear beta-catenin or beta-catenin dependent transcription