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IL8 — SYT1

Text-mined interactions from Literome

Wang et al., Zhonghua Gan Zang Bing Za Zhi 2011 (Carcinoma, Hepatocellular...) : p38 MAPK inhibitor ( SB203580 ) could significantly inhibit IL-8 production in a dose dependent manners ( F = 65.47, P < 0.01 ), and partially inhibited NF-kB p65 nuclear translocation in a dose dependent manner ( F=141.20, P < 0.05 )
Ember et al., J Gen Virol 2012 (Poxviridae Infections...) : Consistent with this, C4 inhibited interleukin-1ß induced translocation of p65 into the nucleus
Byun et al., Biochem Biophys Res Commun 2012 (Inflammation) : In addition, EGCG treated DCs inhibited lipopolysaccharide (LPS) induced production of pro-inflammatory cytokines ( tumor necrosis factor [TNF ] -a, interleukin [ IL]-1ß, and IL-6 ) and activation of mitogen activated protein kinases ( MAPKs ), e.g., extracellular signal regulated kinase 1/2 ( ERK1/2 ), p38, c-Jun N-terminal kinase (JNK), and nuclear factor ?B ( NF-?B ) p65 translocation through 67LR
Takeuchi et al., PLoS Pathog 2013 : NF-?B is a transcriptional regulator that controls important aspects of innate immune responses, and NF-?B RelA/p65 homodimers regulate transcription of IL8
Kunsch et al., J Immunol 1994 : Synergistic transcriptional activation of the IL-8 gene by NF-kappa B p65 ( RelA ) and NF-IL-6
Harant et al., Eur J Biochem 1997 : Furthermore, overexpression of VDR in the parental G-361 cell line enhanced the repressive effect of calcitriol on activation of the IL-8 promoter by either TNF-alpha stimulation or overexpression of the NF-kappaB subunit p65