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IGF2 — IL8

Text-mined interactions from Literome

Garrouste et al., Cell Death Differ 2002 : Correspondingly, IGF-I markedly enhanced the TNF- and IFN/TNF induced NF-kappaB dependent interleukin-8 production
Kim et al., Biochem Biophys Res Commun 2004 (MAP Kinase Signaling System) : Differential regulation of IGF-II induced IL-8 by extracellular signal regulated kinase 1/2 and p38 mitogen activated protein kinases in human keratinocytes ... The upregulation of IL-8 expression by IGF-II was reduced by pretreatment with inhibitors of tyrosine kinase, Src, PI3-kinase, and ERK, but not by p38 ... Furthermore, IGF-II remarkably increased the DNA binding activities of NF-kappaB and AP-1, and the IL-8 promoter activity ... However, cotransfection with IkappaB mutant blocked the IGF-II induced IL-8 promoter activity ... In addition, cotransfection with dominant negative MEK1 mutant, but not with dominant negative p38 mutant, blocked the IGF-II induced IL-8 promoter activity ... These results suggest that IGF-II is involved in the pathogenesis of psoriasis by inducing IL-8 gene expression through the tyrosine kinase-Src-ERK1/2-AP-1 pathway, and the PI3-kinase and NF-kappaB pathway