Nisimoto et al., Biochemistry 2004
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In the presence of Rac , p67N or p67phox bound to gp91C with a molar ratio of approximately 1 : 1 but neither p67N nor Rac alone showed significant binding
Robinson et al., Histochem Cell Biol 2004
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X-ray crystallography and NMR spectroscopy have provided detailed structural data on these domains and how p47-phox and p67-phox interact with p22-phox and activated Rac , respectively
Choi et al., Int Immunopharmacol 2006
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Translocation of p47(phox), p67(phox) and Rac was increased in response to PMA, and Tau-Cl inhibited the PMA stimulated translocation of p47(phox) and p67(phox) to plasma membrane without affecting the translocation of Rac
Dorseuil et al., J Biol Chem 1996
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These results indicate that activated Rac can regulate NADPH oxidase by interacting with p67phox and that Rac2 is the main p67phox interacting GTPase in human cells