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Wang et al., J Biol Chem 2010
(Cardiomegaly) :
miR-9 and NFATc3
regulate myocardin in cardiac hypertrophy ... Our data reveal that
miR-9 can
suppress myocardin expression
Wang et al., J Biol Chem 2010
:
Our data demonstrated that myocardin significantly represses versican expression in multiple cell lines, and this occurs through the
induction of
miR-143 by
myocardin
Chen et al., Arterioscler Thromb Vasc Biol 2011
:
In this study, we investigated whether
myocardin induces
miR-1 expression to mediate its inhibitory effects on SMC proliferation ... Using tetracycline regulated expression ( T-REx ) inducible system expressing myocardin in human vascular SMCs, we found that overexpression of
myocardin resulted in significant induction of
miR-1 expression and inhibition of SMC proliferation, which was reversed by miR-1 inhibitors
Chen et al., J Biol Chem 2013
:
Myocardin induced expression of miRs-143/145 and
miR-133a and increased SRF binding to these genes in 10T1/2 cells ... In Brg1-null SW13 cells, miRs-143/145 were dramatically
induced by
myocardin only in the presence of Brg1, whereas
miR-133 was not induced by myocardin in a Brg1 dependent manner