Cho et al., J Cell Physiol 2010
(Calcinosis) :
Overexpression of miR-146a induced the inhibition of IRAK1 expression and inhibited basal and TNF-alpha- and TLR ligand induced osteogenic differentiation
Hulsmans et al., PloS one 2012
(Inflammation...) :
Silencing of miR-146b-5p with an antisense inhibitor resulted in increased expression of IRAK1 and TRAF6 leading to more NF?B p65 DNA binding activity and TNFa
Chassin et al., EMBO Mol Med 2012
(Ischemia...) :
Importantly, administration of microRNA (miR)-146a or induction of miR-146a by the phytochemical diindolylmethane controlled Irak1 upregulation and prevented immune hyper-responsiveness in mouse and human tissue
Quinn et al., PloS one 2013
:
Furthermore, overexpression of miR-146a resulted in strong reduction in IRAK-1 and phosphorylated I?Ba expression in naive and S. typhimurium stimulated THP-1 cells