◀ Back to PI3

IL6 — PI3

Text-mined interactions from Literome

Thabard et al., Cytokine 2001 (MAP Kinase Signaling System...) : In OPM-2 cells, IL-6 , OSM and LIF induce both signal transducers and activators of transcription ( STAT ), mitogen activated protein kinase ( MAPK ) and phosphatidylinositol 3-kinase (PI 3-K) activation
Ajuwon et al., J Nutr 2005 : However, the phosphoinositide-3 kinase (PI3K) inhibitor, wortmannin, alone and additively with palmitate, activated the NF-kappaB reporter gene and induced IL-6 expression ( P < 0.05 ). Palmitate also induced the mRNA expression of tumor necrosis factor alpha (TNFalpha) ( P < 0.05 ), but the increase in mRNA abundance was not reflected in a greater protein concentration in the media ( P > 0.05 )
Smart et al., Cardiovasc Res 2006 (Myocardial Reperfusion Injury) : IL-6 induces PI 3-kinase and nitric oxide dependent protection and preserves mitochondrial function in cardiomyocytes
Hanai et al., J Cell Biochem 2006 : In the present study, we investigated whether the phosphatidylinositol 3-kinase (PI3K)/Akt is involved in the PDGF-BB induced IL-6 synthesis in osteoblast-like MC3T3-E1 cells
Takai et al., Horm Metab Res 2006 : These results strongly suggest that PI3-kinase/Akt plays a role in the TNF-alpha stimulated IL-6 synthesis mainly independent of p44/p42 MAP kinase in osteoblasts
Lee et al., American journal of physiology. Renal physiology 2007 : IL-6 also increased the phosphorylation of signal transducer and activator of transcription-3 ( STAT3 ), phosphoinositide-3 kinase (PI3K)/Akt , and mitogen activated protein kinases ( MAPKs ) in a time dependent manner
Tang et al., J Immunol 2007 : Leptin mediated IL-6 production was attenuated by OBRl receptor antisense oligonucleotide, PI3K inhibitor ( Ly294002 and wortmannin ), Akt inhibitor ( 1L-6-hydroxymethyl-chiro-inositol-2- ( ( R ) -2-O-methyl-3-O-octadecylcarbonate ) ), NF-kappaB inhibitor ( pyrrolidine dithiocarbamate ), IkappaB protease inhibitor ( L-1-tosylamido-2-phenylenylethyl chloromethyl ketone ), IkappaBalpha phosphorylation inhibitor ( Bay 117082 ), or NF-kappaB inhibitor peptide
Tokuda et al., Prostaglandins Leukot Essent Fatty Acids 2007 : In addition, we recently showed that phosphatidylinositol 3 (PI3)-kinase activated by platelet derived growth factor-BB ( PDGF-BB ) negatively regulates the interleukin-6 synthesis in these cells
Dommisch et al., Int Endod J 2008 : To investigate the involvement of the phosphatidylinositol-3-kinase (PI3K) in interleukin-6 (IL-6) and interleukin-8 (IL-8) gene expression in odontoblast-like cells when exposed to heat killed Streptococcus mutans
Suh et al., J Cell Physiol 2009 : In addition, IL-6 increased EGFR/src/FAK, PI3K/Akt phosphorylation and 2-DG uptake as well as GLUT-2 protein expression, which were blocked by AG 1478 ( EGF receptor inhibitor ), PP2 ( src family of tyrosine kinase inhibitor ), PI3K-specific siRNA, and a Akt inhibitor
Yang et al., Microvasc Res 2009 (AIDS Dementia Complex) : Inhibitors of STAT1, mitogen activated protein kinase kinase ( MEK ) ( PD98059 ), and phosphatidyl inositol 3 kinase (PI3K) ( LY294002 ), blocked gp120 induced STAT1 activation and significantly diminished IL-8-, IL-6- , and gp120 induced monocyte adhesion and migration across in vitro BBB models
Walton et al., Am J Physiol Gastrointest Liver Physiol 2009 : Inhibition of phosphoinositide-3 (PI3)-kinase , p38 MAPK, or NF-kappaB pathways reduced LPS induced PGE2, IL-6 , and KC secretion
Westra et al., Ann N Y Acad Sci 2009 (Arthritis, Rheumatoid) : Protein and mRNA expression of HIF-1alpha and the effects of inhibitors of the CaMKII-, PI3K- , and ERK pathway on VEGF and IL-6 production were analyzed
Kim et al., Immune network 2011 : Both TNF-a and IL-6 production by HBHA was regulated by the NF-?B, PI3-K , and MAPK pathways
Muraoka et al., Clin Exp Rheumatol 2013 (Arthritis, Rheumatoid) : Effects of inhibitors of janus kinase 2 (JAK2), phosphatidylinositol 3-kinase (PI3K) , and mitogen activated protein kinase ( MAPK ) on IL-6 production were evaluated