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CDH13 — PI3

Text-mined interactions from Literome

Goodwin et al., J Biol Chem 2003 : In particular, homophilic cadherin ligation can directly activate Rho family GTPases and phosphatidylinositol 3-kinase ( PI3-kinase ), signaling molecules with the capacity to support the morphogenetic effects of these adhesion molecules during development and disease ... In contrast, cadherin activated PI3-kinase signaling was not affected by loss of p120-ctn binding
Owens et al., J Cell Sci 2003 (Cell Transformation, Neoplastic...) : Responsiveness to TGFbeta could be restored by inhibiting cadherin mediated cell-cell adhesion or phosphoinositide 3-kinase (PI3-K) activity, but not by inhibiting mitogen activated protein kinase ( MAPK ) activity
Takahashi et al., J Cell Physiol 1999 : In contrast, tyrosine phosphorylation of p115 or p 105 was undetectable by immunoblot with IGF-I stimulation, and PI 3-kinase activity was mediated via IRS-1 phosphorylated with IGF-I stimulation, little of which was associated with SHP-2