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CXCL12 — PHKA2

Text-mined interactions from Literome

Hecht et al., J Leukoc Biol 2004 : This inhibition was accompanied by attenuation of CXCL12 induced Pyk2 phosphorylation but did not involve internalization of the CXCL12 receptor, CXCR4, or phosphorylation of extracellular regulated kinase
Okabe et al., Blood 2005 : SDF-1alpha/CXCL12 induced the tyrosine phosphorylation of Pyk2 and the association of Pyk2 with zeta chain associated protein-70 kilodaltons ( Zap-70 ) and Vav
Florio et al., Mol Pharmacol 2006 (Adenoma...) : To identify a possible cross-talk and a molecular ordering among these pathways, we tested these antagonists on SDF1alpha dependent activation of ERK1/2, Pyk2 , and BK ( Ca ) channels
Massa et al., Ann N Y Acad Sci 2006 (Adenoma...) : SDF-1 increased cytosolic [ Ca2+ ] and activated Pyk2 , ERK1/2, and BKCa channels ... To identify a possible crosstalk and a molecular ordering among these pathways, we tested these antagonists on SDF-1 dependent activation of ERK1/2, Pyk2 , and BKCa channels
Chen et al., Blood 2008 : Furthermore, we found that Rap1b deficiency had no marked effect on LPS-, BCR-, or SDF-1 induced activation of mitogen activated protein kinases and AKT but clearly impaired SDF-1 mediated activation of Pyk-2 , a key regulator of SDF-1 mediated B-cell migration
Agle et al., J Biol Chem 2010 (Calcium Signaling) : Immunoblot analyses demonstrated CXCL12 activated the calcium regulated focal adhesion protein proline-rich tyrosine kinase-2 (Pyk2) and the effector proteins paxillin and p130 ( Cas )