◀ Back to TNF
STAT1 — TNF
Pathways - manually collected, often from reviews:
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OpenBEL Selventa BEL large corpus:
TNF
→
STAT1
(decreases)
Ji et al., J Exp Med 2003*
Evidence: IL-10 strongly inhibited TNFalpha production in control macrophages incubated with erythrocytes (Es). In contrast when macrophages were incubated with IgG-opsonized erythrocytes, (E-IgGs) they suppressed the ability of IL-10 to inhibit TNFalpha production.
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NCI Pathway Database TNF receptor signaling pathway :
FADD (FADD)
→
sTNF-alpha/TNFR1A/TRADD/STAT1 (dimer) complex (TNFRSF1A-TRADD-STAT1-TNF)
(modification, collaborate)
Schneider-Brachert et al., Immunity 2004, Schneider-Brachert et al., J Clin Invest 2006, Hsu et al., Cell 1996
Evidence: mutant phenotype, assay, physical interaction
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NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/TRAF2 complex (TNFRSF1A-TRADD-TRAF2-TNF)
→
sTNF-alpha/TNFR1A/TRADD/STAT1 (dimer) complex (TNFRSF1A-TRADD-STAT1-TNF)
(modification, collaborate)
Schneider-Brachert et al., Immunity 2004, Schneider-Brachert et al., J Clin Invest 2006, Hsu et al., Cell 1996
Evidence: mutant phenotype, assay, physical interaction
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NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-TNF)
→
sTNF-alpha/TNFR1A/TRADD/STAT1 (dimer) complex (TNFRSF1A-TRADD-STAT1-TNF)
(modification, collaborate)
Wang et al., Mol Cell Biol 2000, Trompouki et al., Nature 2003, Brummelkamp et al., Nature 2003, Kovalenko et al., Nature 2003, Li et al., J Biol Chem 2006, Ea et al., Mol Cell 2006, Hsu et al., Cell 1996, Hsu et al., Immunity 1996, Jiang et al., Science 1999
Evidence: mutant phenotype, assay, physical interaction
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NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-TNF)
→
STAT1 (STAT1)
(modification, collaborate)
Wang et al., Mol Cell Biol 2000, Trompouki et al., Nature 2003, Brummelkamp et al., Nature 2003, Kovalenko et al., Nature 2003, Li et al., J Biol Chem 2006, Ea et al., Mol Cell 2006, Hsu et al., Cell 1996, Hsu et al., Immunity 1996, Jiang et al., Science 1999
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD complex (TNFRSF1A-TRADD-TNF)
→
sTNF-alpha/TNFR1A/TRADD/STAT1 (dimer) complex (TNFRSF1A-TRADD-STAT1-TNF)
(modification, collaborate)
Wang et al., Mol Cell Biol 2000, Trompouki et al., Nature 2003, Brummelkamp et al., Nature 2003, Kovalenko et al., Nature 2003, Li et al., J Biol Chem 2006, Ea et al., Mol Cell 2006, Hsu et al., Cell 1996, Hsu et al., Immunity 1996, Jiang et al., Science 1999
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD complex (TNFRSF1A-TRADD-TNF)
→
STAT1 (STAT1)
(modification, collaborate)
Wang et al., Mol Cell Biol 2000, Trompouki et al., Nature 2003, Brummelkamp et al., Nature 2003, Kovalenko et al., Nature 2003, Li et al., J Biol Chem 2006, Ea et al., Mol Cell 2006, Hsu et al., Cell 1996, Hsu et al., Immunity 1996, Jiang et al., Science 1999
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/STAT1 (dimer) complex (TNFRSF1A-TRADD-STAT1-TNF)
→
STAT1 (STAT1)
(modification, collaborate)
Wang et al., Mol Cell Biol 2000, Trompouki et al., Nature 2003, Brummelkamp et al., Nature 2003, Kovalenko et al., Nature 2003, Li et al., J Biol Chem 2006, Ea et al., Mol Cell 2006, Hsu et al., Cell 1996, Hsu et al., Immunity 1996, Jiang et al., Science 1999
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/STAT1 (dimer) complex (TNFRSF1A-TRADD-STAT1-TNF)
→
RIP (RIPK1)
(modification, collaborate)
Wang et al., Mol Cell Biol 2000, Trompouki et al., Nature 2003, Brummelkamp et al., Nature 2003, Kovalenko et al., Nature 2003, Li et al., J Biol Chem 2006, Ea et al., Mol Cell 2006, Hsu et al., Cell 1996, Hsu et al., Immunity 1996, Jiang et al., Science 1999
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/STAT1 (dimer) complex (TNFRSF1A-TRADD-STAT1-TNF)
→
TRAF2 (TRAF2)
(modification, collaborate)
Wang et al., Mol Cell Biol 2000, Trompouki et al., Nature 2003, Brummelkamp et al., Nature 2003, Kovalenko et al., Nature 2003, Li et al., J Biol Chem 2006, Ea et al., Mol Cell 2006, Hsu et al., Cell 1996, Hsu et al., Immunity 1996, Jiang et al., Science 1999
Evidence: mutant phenotype, assay, physical interaction
Text-mined interactions from Literome
Han et al., J Interferon Cytokine Res 1999
:
We describe a novel mechanism of signaling interaction through which
tumor necrosis factor-alpha (TNF-alpha) treatment
augments interferon-gamma (IFN-gamma) induced
Stat1alpha DNA binding complexes and transcriptional activation of a Stat binding element
Sekine et al., J Cell Physiol 2000
:
TNF-alpha did not
affect STAT1 activation, but stimulated DNA binding and transcriptional activity of NF-kappaB, both of which were further increased by IFN-gamma
Mukhopadhyay et al., J Cell Biochem 2002
:
Here, we report our investigation of the
role of
STAT1 in
TNF signaling using STAT1-deficient U3A and STAT1-stably transfected U3A-PSG91 cells
Badgwell et al., Surgery 2002
(Escherichia coli Infections...) :
The 2 groups of mice were analyzed for serum levels of interferon-gamma,
tumor necrosis factor-alpha , and interleukin-1beta as well as
activation of NFkappaB and
STAT1 , 2 proinflammatory transcription factors
Nguyen et al., J Interferon Cytokine Res 2003
:
IL-1 and
tumor necrosis factor (TNF) enhance the serine phosphorylation of
Stat1 that occurs in response to interferon-gamma (IFN-gamma) and potentiate IFN-gamma mediated, Stat1-driven gene expression, thus contributing to the synergistic activities of these proinflammatory cytokines
Tliba et al., J Biol Chem 2003
(Inflammation) :
In this study,
TNFalpha in a time dependent manner activated both janus tyrosine kinase 1 and Tyk2 tyrosine kinase and
increased the nuclear translocation of interferon-regulatory factor-1,
STAT1 , and STAT2 in human airway smooth muscle cells
Yu et al., J Biol Chem 2004
:
This difference seemed to be underlain by differential induction of signal transducers and activators of transcription ( STAT ) activation in that, whereas flagellin and
TNFalpha seemed to be equipotent activators of p38 mitogen activated protein kinase and nuclear factor-kappaB, flagellin
induced substantially higher levels of
STAT-1 and -3 tyrosine phosphorylation
Jensen et al., J Endocrinol 2005
:
Gel retardation experiments showed that hGH affects neither
IFN-gamma+TNF-alpha induced
STAT1 DNA binding nor IL-1beta and IFN-gamma+TNF-alpha induced NFkappaB DNA binding
Ganster et al., J Interferon Cytokine Res 2005
(Inflammation) :
Interestingly, IFN-gamma pretreatment of 2fTGH fibroblasts potentiates
TNF-alpha induction of
Stat1 DNA binding
Liu et al., Zhonghua Wai Ke Za Zhi 2006
:
STAT1 and STAT3 might be
involved in the regulation of
TNF-alpha gene expression, but not in TNF-alpha early release ( < 24 hours ) induced by HMGB1 stimulation in rat peritoneal macrophages
Robinson et al., J Am Coll Surg 2006
:
Peptide YY attenuates
STAT1 and STAT3 activation
induced by
TNF-alpha in acinar cell line AR42J ... We hypothesized that
tumor necrosis factor (TNF)-alpha would
induce STAT1 and STAT3, and PYY would attenuate their transcription factor binding ... Results from both the electrophoretic mobility shift assay- and the ELISA based assays verified
STAT1 and STAT3
responses to
TNF-alpha and PYY ... In pancreatic acinar cells,
TNF-alpha activated
STAT1 and STAT3, known mediators of inflammatory cytokines
Bennett et al., Blood 2006
(Inflammation...) :
Thus, knock-down of RAX expression by 80 % using small interfering RNA ( siRNA ) prevents
IFNgamma/tumor necrosis factor alpha (TNFalpha) induced PKR activation and eIF2alpha phosphorylation, IkappaB degradation, IRF-1 expression, and
STAT1 phosphorylation, resulting in enhanced murine embryonic fibroblast (MEF) cell survival
Ishiguro et al., Toxicol Appl Pharmacol 2006
(Colitis) :
Furthermore, Paeonol reduced
TNFalpha induced NF-kappaB transactivation and IFNgamma induced
STAT1 transactivation in CW-2 cells and also in Jurkat cells
D'Alimonte et al., J Immunol 2007
:
Guanosine effects were mediated by an increased phosphorylation of Akt, a PI3K downstream effector, as well as of ERK1/2 and p38 in the MAPK system, because culture pretreatment with selective ERK1/2, p38 MAPK, and PI3K antagonists ( U0126, SB203580, or LY294002, respectively ) counteracted guanosine inhibition on
IFN-gamma/TNF-alpha induced CD40 expression and function as well as on
STAT-1alpha or NF-kappaB nuclear translocation
Matsumiya et al., J Immunol 2007
(Uterine Cervical Neoplasms) :
IFN-epsilon mediates
TNF-alpha induced
STAT1 phosphorylation and induction of retinoic acid-inducible gene-I in human cervical cancer cells ... Our findings support a sequential mechanism whereby
TNF-alpha leads to stabilization of IFN-epsilon mRNA, increased IFN-epsilon synthesis, engagement of type I IFNRs, increased
STAT1 expression and phosphorylation, and up-regulation of RIG-I expression
Liu et al., J Immunol 2007
:
Activation of NF-kappaB, STAT6, and
STAT1 was
induced in eosinophils by
TNF-alpha , IL-4, and IFN-gamma, respectively
Kanda et al., Am J Physiol Cell Physiol 2007
:
These results suggest that histamine stimulates H1 receptor and potentiates
TNF-alpha- or IFN-gamma induced hBD-2 production
dependent on NF-kappaB, AP-1, or
STAT1 in human keratinocytes
Hu et al., J Leukoc Biol 2008
:
Instead,
TNF-alpha and PGE2
increased Stat1 serine phosphorylation and Stat4 tyrosine phosphorylation and activated expression of the NF-kappaB and Stat1 target gene IFN regulatory factor 1 (IRF1), which contributes to IFN responses
Ju et al., Biochem Biophys Res Commun 2009
:
PGG significantly inhibited
TNF-alpha/IFN-gamma induced NF-kappaB activation as well as
STAT1 activation
Lee et al., Mol Cell 2009
(Inflammation) :
LXR ligands inhibit neither STAT1 phosphorylation nor
STAT1 translocation to the nucleus but, rather,
inhibit STAT1 binding to promoters and the expression of IRF1,
TNFalpha , and IL-6, downstream effectors of STAT1 action
Homma et al., Int Arch Allergy Immunol 2010
:
Cooperative
activation of CCL5 expression by TLR3 and
tumor necrosis factor-alpha or interferon-gamma through nuclear factor-kappaB or
STAT-1 in airway epithelial cells
Han et al., Environ Toxicol Pharmacol 2011
(Dermatitis, Atopic) :
Additionally, PGEA inhibited the
TNF-a/IFN-?-co induced activation of NF-?B and
STAT1 and increased the expression of heme oxygenase-1 (HO-1) protein and mRNA
Rosengren et al., Ann Rheum Dis 2012
(Arthritis, Rheumatoid) :
TNF induced early interferon ( IFN ) ß expression and
STAT1 phosphorylation beginning at 3 h, which was blocked by CP-690,550
Stephens et al., J Biol Chem 1996
:
Only
STAT 1 is
down-regulated by
TNF alpha in fully differentiated cells
Farivar et al., J Biol Chem 1996
:
Tumor necrosis factor-alpha and interferon-gamma
induced NF-kappaB ( p50/p65 ) and
STAT-1 , respectively, as assessed by gel shift assays
McDonald et al., Biochemistry 1998
:
To circumvent this problem, we developed an alternative procedure which allowed us to show that in neutrophils, LPS and
TNFalpha induce a NF-kappaB DNA binding activity which essentially consists of p50/RelA dimers, and that IFNgamma
promotes the binding of
STAT1 homodimers to the IFNgamma response region of the FcgammaRI promoter
Agresti et al., Eur J Neurosci 1998
:
The existence of a synergism between IFN-gamma and TNF-alpha in stimulating IRF-1 expression at the transcriptional level was supported by IRF-1 promoter analysis : IFN-gamma directly
induced the binding of
STAT-1 homodimers to the GAS element, while NF-kappaB binding to the kappaB sequence was activated by
TNF-alpha only after IFN-gamma treatment