Gene interactions and pathways from curated databases and text-mining

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STAT1 — TNF

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Han et al., J Interferon Cytokine Res 1999 : We describe a novel mechanism of signaling interaction through which tumor necrosis factor-alpha (TNF-alpha) treatment augments interferon-gamma (IFN-gamma) induced Stat1alpha DNA binding complexes and transcriptional activation of a Stat binding element
Sekine et al., J Cell Physiol 2000 : TNF-alpha did not affect STAT1 activation, but stimulated DNA binding and transcriptional activity of NF-kappaB, both of which were further increased by IFN-gamma
Mukhopadhyay et al., J Cell Biochem 2002 : Here, we report our investigation of the role of STAT1 in TNF signaling using STAT1-deficient U3A and STAT1-stably transfected U3A-PSG91 cells
Badgwell et al., Surgery 2002 (Escherichia coli Infections...) : The 2 groups of mice were analyzed for serum levels of interferon-gamma, tumor necrosis factor-alpha , and interleukin-1beta as well as activation of NFkappaB and STAT1 , 2 proinflammatory transcription factors
Nguyen et al., J Interferon Cytokine Res 2003 : IL-1 and tumor necrosis factor (TNF) enhance the serine phosphorylation of Stat1 that occurs in response to interferon-gamma (IFN-gamma) and potentiate IFN-gamma mediated, Stat1-driven gene expression, thus contributing to the synergistic activities of these proinflammatory cytokines
Tliba et al., J Biol Chem 2003 (Inflammation) : In this study, TNFalpha in a time dependent manner activated both janus tyrosine kinase 1 and Tyk2 tyrosine kinase and increased the nuclear translocation of interferon-regulatory factor-1, STAT1 , and STAT2 in human airway smooth muscle cells
Yu et al., J Biol Chem 2004 : This difference seemed to be underlain by differential induction of signal transducers and activators of transcription ( STAT ) activation in that, whereas flagellin and TNFalpha seemed to be equipotent activators of p38 mitogen activated protein kinase and nuclear factor-kappaB, flagellin induced substantially higher levels of STAT-1 and -3 tyrosine phosphorylation
Jensen et al., J Endocrinol 2005 : Gel retardation experiments showed that hGH affects neither IFN-gamma+TNF-alpha induced STAT1 DNA binding nor IL-1beta and IFN-gamma+TNF-alpha induced NFkappaB DNA binding
Ganster et al., J Interferon Cytokine Res 2005 (Inflammation) : Interestingly, IFN-gamma pretreatment of 2fTGH fibroblasts potentiates TNF-alpha induction of Stat1 DNA binding
Liu et al., Zhonghua Wai Ke Za Zhi 2006 : STAT1 and STAT3 might be involved in the regulation of TNF-alpha gene expression, but not in TNF-alpha early release ( < 24 hours ) induced by HMGB1 stimulation in rat peritoneal macrophages
Robinson et al., J Am Coll Surg 2006 : Peptide YY attenuates STAT1 and STAT3 activation induced by TNF-alpha in acinar cell line AR42J ... We hypothesized that tumor necrosis factor (TNF)-alpha would induce STAT1 and STAT3, and PYY would attenuate their transcription factor binding ... Results from both the electrophoretic mobility shift assay- and the ELISA based assays verified STAT1 and STAT3 responses to TNF-alpha and PYY ... In pancreatic acinar cells, TNF-alpha activated STAT1 and STAT3, known mediators of inflammatory cytokines
Bennett et al., Blood 2006 (Inflammation...) : Thus, knock-down of RAX expression by 80 % using small interfering RNA ( siRNA ) prevents IFNgamma/tumor necrosis factor alpha (TNFalpha) induced PKR activation and eIF2alpha phosphorylation, IkappaB degradation, IRF-1 expression, and STAT1 phosphorylation, resulting in enhanced murine embryonic fibroblast (MEF) cell survival
Ishiguro et al., Toxicol Appl Pharmacol 2006 (Colitis) : Furthermore, Paeonol reduced TNFalpha induced NF-kappaB transactivation and IFNgamma induced STAT1 transactivation in CW-2 cells and also in Jurkat cells
D'Alimonte et al., J Immunol 2007 : Guanosine effects were mediated by an increased phosphorylation of Akt, a PI3K downstream effector, as well as of ERK1/2 and p38 in the MAPK system, because culture pretreatment with selective ERK1/2, p38 MAPK, and PI3K antagonists ( U0126, SB203580, or LY294002, respectively ) counteracted guanosine inhibition on IFN-gamma/TNF-alpha induced CD40 expression and function as well as on STAT-1alpha or NF-kappaB nuclear translocation
Matsumiya et al., J Immunol 2007 (Uterine Cervical Neoplasms) : IFN-epsilon mediates TNF-alpha induced STAT1 phosphorylation and induction of retinoic acid-inducible gene-I in human cervical cancer cells ... Our findings support a sequential mechanism whereby TNF-alpha leads to stabilization of IFN-epsilon mRNA, increased IFN-epsilon synthesis, engagement of type I IFNRs, increased STAT1 expression and phosphorylation, and up-regulation of RIG-I expression
Liu et al., J Immunol 2007 : Activation of NF-kappaB, STAT6, and STAT1 was induced in eosinophils by TNF-alpha , IL-4, and IFN-gamma, respectively
Kanda et al., Am J Physiol Cell Physiol 2007 : These results suggest that histamine stimulates H1 receptor and potentiates TNF-alpha- or IFN-gamma induced hBD-2 production dependent on NF-kappaB, AP-1, or STAT1 in human keratinocytes
Hu et al., J Leukoc Biol 2008 : Instead, TNF-alpha and PGE2 increased Stat1 serine phosphorylation and Stat4 tyrosine phosphorylation and activated expression of the NF-kappaB and Stat1 target gene IFN regulatory factor 1 (IRF1), which contributes to IFN responses
Ju et al., Biochem Biophys Res Commun 2009 : PGG significantly inhibited TNF-alpha/IFN-gamma induced NF-kappaB activation as well as STAT1 activation
Lee et al., Mol Cell 2009 (Inflammation) : LXR ligands inhibit neither STAT1 phosphorylation nor STAT1 translocation to the nucleus but, rather, inhibit STAT1 binding to promoters and the expression of IRF1, TNFalpha , and IL-6, downstream effectors of STAT1 action
Homma et al., Int Arch Allergy Immunol 2010 : Cooperative activation of CCL5 expression by TLR3 and tumor necrosis factor-alpha or interferon-gamma through nuclear factor-kappaB or STAT-1 in airway epithelial cells
Han et al., Environ Toxicol Pharmacol 2011 (Dermatitis, Atopic) : Additionally, PGEA inhibited the TNF-a/IFN-?-co induced activation of NF-?B and STAT1 and increased the expression of heme oxygenase-1 (HO-1) protein and mRNA
Rosengren et al., Ann Rheum Dis 2012 (Arthritis, Rheumatoid) : TNF induced early interferon ( IFN ) ß expression and STAT1 phosphorylation beginning at 3 h, which was blocked by CP-690,550
Stephens et al., J Biol Chem 1996 : Only STAT 1 is down-regulated by TNF alpha in fully differentiated cells
Farivar et al., J Biol Chem 1996 : Tumor necrosis factor-alpha and interferon-gamma induced NF-kappaB ( p50/p65 ) and STAT-1 , respectively, as assessed by gel shift assays
McDonald et al., Biochemistry 1998 : To circumvent this problem, we developed an alternative procedure which allowed us to show that in neutrophils, LPS and TNFalpha induce a NF-kappaB DNA binding activity which essentially consists of p50/RelA dimers, and that IFNgamma promotes the binding of STAT1 homodimers to the IFNgamma response region of the FcgammaRI promoter
Agresti et al., Eur J Neurosci 1998 : The existence of a synergism between IFN-gamma and TNF-alpha in stimulating IRF-1 expression at the transcriptional level was supported by IRF-1 promoter analysis : IFN-gamma directly induced the binding of STAT-1 homodimers to the GAS element, while NF-kappaB binding to the kappaB sequence was activated by TNF-alpha only after IFN-gamma treatment