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EGFR — IL6
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Gao et al., J Clin Invest 2007
(Adenocarcinoma...) :
Furthermore, inhibition of
EGFR activity in multiple cell lines partially
blocked transcription of
IL-6 and concurrently decreased production and release of IL-6
Ma et al., Int J Cancer 2008
(Carcinoma...) :
In vitro cell system, nuclear accumulation of
EGFR was observed in LMP1 expressing cells, and
IL-6 induced phosphorylated STAT3 and iNOS
Suh et al., J Cell Physiol 2009
:
In addition,
IL-6 increased
EGFR/src/FAK , PI3K/Akt phosphorylation and 2-DG uptake as well as GLUT-2 protein expression, which were blocked by AG 1478 ( EGF receptor inhibitor ), PP2 ( src family of tyrosine kinase inhibitor ), PI3K-specific siRNA, and a Akt inhibitor
Wu et al., J Neurosurg 2010
(Brain Injuries...) :
Simvastatin modified the caveolin-1 expression in lipid rafts in astrocyte cell membrane, suppressed the phosphorylation of
EGFR in lipid rafts of astrocytes after OGD, and
inhibited the OGD induced
interleukin-1 production
Chen et al., Int J Radiat Oncol Biol Phys 2010
(Carcinoma, Squamous Cell...) :
In vitro, either extrinsic IL-6 stimulation of cancer cells or intrinsically activated
IL-6 signaling detected in FADu-C225-R cells
results in resistance to irradiation and
EGFR inhibitor
Karacsonyi et al., Am J Respir Cell Mol Biol 2012
:
Epidermal growth factor receptor signaling
mediates vesicant induced airway epithelial secretion of
interleukin-6 and production of mucin
Oyama et al., J Dermatol Sci 1998
(Psoriasis) :
Immunodetection and in situ hybridization analyses revealed that
IL-6 induces
EGFR expression in NHKs in a time- and dose dependent manner ... On the other hand, PLKs expressed high levels of
EGFR even when unstimulated and the expression level was not
affected by
IL-6 stimulation