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ARSK — E2F1

Text-mined interactions from Literome

Yamada et al., J Biol Chem 2002 : A 63-base pair DNA segment containing an Sp1 site but not a canonical E2F site can confer growth dependent and E2F mediated transcriptional stimulation of the human ASK gene encoding the regulatory subunit for human Cdc7 related kinase ... Our results suggest that E2F regulates the ASK promoter through an atypical mode of recognition of the target site
Tan et al., J Biol Chem 2006 : We show that ASK1 is directly regulated by E2F1 and that prevention of ASK1 induction by RNA interference decreases SAHA induced apoptosis ... These results indicate that ASK1 induction by E2F1 provides positive feedback regulation of E2F1 activity via Rb inhibition, which allows an efficient E2F1-Bim activation
Dong et al., Tumour Biol 2007 (Melanoma) : Truncated E2F-1 protein, which lacks the transactivation domain, failed to upregulate ASK1, suggesting that ASK1 was regulated at the transcriptional level by E2F-1 ... The ASK1 kinase assay showed that ASK1 activity was not upregulated in response to E2F1 overexpression ... ASK1 expression is upregulated by E2F-1 at the transcription level, but the upregulation of ASK1 expression by E2F-1 was not coordinated with an increased ASK1 activity