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IRS1 — MLST8

Pathways - manually collected, often from reviews:

• NCI Pathway Database mTOR signaling pathway: mTORC1 complex (MTOR-MLST8-RPTOR) → IRS1 (IRS1) (modification, activates) Ozes et al., Proc Natl Acad Sci U S A 2001, Harrington et al., J Cell Biol 2004*, Um et al., Nature 2004*, Tremblay et al., Proc Natl Acad Sci U S A 2007*, Zhang et al., J Biol Chem 2008*
  Evidence: mutant phenotype, assay

Text-mined interactions from Literome

Xu et al., J Biol Chem 2012 : Recent work has implicated a role for cullin-RING E3 ubiquitin ligase 7 ( CRL7 ) in targeting IRS1 for mTORC1/S6K1 dependent degradation
Kim et al., Mol Cell 2012 : Our findings reveal that in addition to persistent mTORC1 signaling, heightened mTORC2 signals can promote insulin resistance due to mTORC2 mediated degradation of IRS-1