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MAP3K1 — MAP3K7

Pathways - manually collected, often from reviews:

• BioCarta nf-kb signaling pathway: TAB1/TAK1 complex (MAP3K7IP1-MAP3K7) → IKK-alpha/MEKK1/NIK complex (CHUK-MAP3K1-MAP4K4) (modification, activates)
  
• NCI Pathway Database BCR signaling pathway: TAK1 (MAP3K7) → MEKK1 (MAP3K1) (modification, activates) Han et al., Immunity 2003
  Evidence: assay, physical interaction, other species
• WikiPathways Cardiac Hypertrophic Response: MAP3K7 → MAP3K1 (activation)
• WikiPathways Cardiac Hypertrophic Response: MAP3K7 → MAP3K1 (activation)
• WikiPathways DNA Damage Response (only ATM dependent): MAP3K1 → Complex of MAP3K4-MAP3K7 (activation)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Hprd Interaction: Complex of 82 proteins (in vivo) Matsuzawa et al., Science 2008

Text-mined interactions from Literome

Hammaker et al., J Immunol 2004 (Arthritis, Rheumatoid...) : Of interest, MEKK1 immunoprecipitates from IL-1 stimulated FLS appeared to activate c-Jun through the JNK pathway and TAK1 activation of c-Jun was dependent on JNK, ERK, and p38
Wang et al., J Biol Chem 1997 : However, because the dominant negative mutants of MEKK1 and MLK3 did not inhibit TAK1 induced JNK activity, we conclude that activation of JNK1 by TAK1 is independent of MEKK1 and MLK3