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GAST — IL8

Text-mined interactions from Literome

Subramaniam et al., Gastroenterology 2008 (Adenocarcinoma...) : Gastrin induces the expression of cyclooxygenase (COX)-2 and interleukin (IL)-8 ; however, the mechanism ( s ), especially in gastric epithelial cells, is not well understood ... Gastrin induced COX-2 and IL-8 expression in AGS-E cells, which was inhibited by phosphatidylinositol 3' kinase (PI3K) and p38 inhibitors ... Gastrin differentially induces COX-2 and IL-8 expression at the transcriptional and posttranscriptional levels by PI3K and p38 mitogen activated protein kinase pathways, respectively
Beales et al., Gastroenterology 1997 : IL-8 ( 1 and 10 nmol/L ) stimulated gastrin release by 34 % +/- 13 % and 43 % +/- 23 % ( P < 0.05 ) above basal, respectively