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PCNA — PIK3CA
Text-mined interactions from Literome
Vlotides et al., Mol Endocrinol 2006
(Pituitary Neoplasms) :
Phosphatidylinositol 3 kinase , protein kinase C, and MAPK, but not c-Jun N-terminal kinase and Janus activating kinase signaling
regulated EGF induced Pttg1, as well as
proliferating cell nuclear antigen mRNA expression and entry into S-phase
Kumar et al., Mol Cell Biol 2006
:
Inhibition of late-G ( 1 )
PI3K activity
results in low c-Myc and
cyclin A expression, impaired Cdk2 activity, and reduced loading of MCM2 ( minichromosome maintenance protein ) onto chromatin
Yang et al., Biochem J 2008
(Breast Neoplasms) :
Inhibition of EGFR,
PI3K ( phosphoinositide 3-kinase ; kinases required for Rac activation by HRG ) or MEK [ MAPK ( mitogen activated protein kinase ) /ERK ( extracellular-signal regulated kinase ) kinase ] also
blocked the up-regulation of
cyclin D1 and p21(Cip1) by HRG