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IL6 — SERPINE1

Text-mined interactions from Literome

Arndt et al., Biochim Biophys Acta 1992 (Carcinoma, Hepatocellular...) : The presence of both interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF) also increased UK and PAI-1 levels, although not as dramatically as IL-1
Dong et al., Hypertens Res 2003 (Acute-Phase Reaction...) : Because the liver is one of the major sources of circulating PAI-1, we here examined the effects of two proinflammatory cytokines, interleukin (IL)-1beta , and IL-6, on PAI-1 production in a human hepatoma cell line, HepG2 ... IL-1beta ( 1 ng/ml ) and IL-6 ( 1 ng/ml ) increased the accumulation of PAI-1 in the conditioned media over 24 h ( IL-1beta : 2.1 +/- 0.2 ( mean +/- SD ) fold over the control ; IL-6 : 1.4 +/- 0.2 fold ; Western blot, p < 0.05 ) ... An HMG-CoA reductase inhibitor ( mevastatin, 10 micromol/l ) attenuated the PAI-1 production induced by IL-1beta and IL-6 ... Thus, 1 ) IL-1beta and IL-6 can increase PAI-1 production in hepatic cells and 2 ) mevastatin may exert anti-thrombotic effects by decreasing the PAI-1 protein production induced by these proinflammatory cytokines
Dong et al., Arterioscler Thromb Vasc Biol 2005 (Atherosclerosis...) : Transient transfection and luciferase assay in HepG2 human hepatoma derived cells demonstrated that IL-6 increased PAI-1 promoter activity and mevastatin decreased IL-6-inducible response ... IL-6 also increased PAI-1 and C/EBPdelta mRNA in mouse primary hepatocytes ... IL-6 increases hepatic PAI-1 expression mediated by the -232- to -210-bp region of the promoter containing a C/EBPdelta binding site
Rega et al., Circulation 2005 (Inflammation) : We used tissue explants and primary cultures of preadipocytes and adipocytes from human subcutaneous and visceral adipose tissue to investigate whether IL-6 and OSM affect PAI-1 expression in fat
Niiya et al., Rinsho Ketsueki 1991 (Leukemia, Promyelocytic, Acute) : As with the case of PMA, TNF-alpha and IL-6 induced PL-21 cells to macrophage-like cells, but did not affect the PAI activity
Faber et al., Nutrition & diabetes 2012 : IL-6 and IL-1ß produced by ( pre ) adipocytes were the strongest inducers of fibrinogen and PAI-1 secretion, respectively
Woodson et al., Virus Res 2013 : Our findings indicate that YFV infection does affect the transcriptional and translational expression of FBG and PAI-1 in human hepatocytes and that these results are further affected by IL-6 during early stages of infection
Thorgersen et al., Infect Immun 2013 (Inflammation...) : Interleukin-6 (IL-6) was significantly inhibited in all organs, IL-1ß and IP-10 were significantly inhibited in liver, spleen, and kidneys, and tumor necrosis factor, IL-8, and PAI-1 were inhibited only in the spleen
Samad et al., Biochim Biophys Acta 1994 : A rapid increase ( 5-6-fold ) in PAI-1 mRNA levels was found between 3 and 12 h. Nuclear run-on assays using a maximum dose of IL-6 showed that IL-6 increases a 4-fold rate of transcription of the PAI-1 gene
Li et al., Arterioscler Thromb Vasc Biol 1997 (Arteriosclerosis...) : The positive control interleukin-1 increased both 2/2 and 1/1 PAI-1 mRNA levels by approximately 5- to 6-fold