◀ Back to MAPK1
ELK1 — MAPK1
Pathways - manually collected, often from reviews:
-
BioCarta mapkinase signaling pathway:
ERK1/ERK2 (MAPK3/MAPK1)
→
ELK-1 (ELK1)
(modification, activates)
-
BioCarta fmlp induced chemokine gene expression in hmc-1 cells:
ERK2 (MAPK1)
→
ELK-1 (ELK1)
(modification, activates)
-
BioCarta erk1/erk2 mapk signaling pathway:
ERK2 (MAPK1)
→
ELK-1 (ELK1)
(modification, activates)
-
KEGG Focal adhesion:
MAPK1/MAPK3
→
ELK1
(protein-protein, phosphorylation)
-
KEGG Insulin signaling pathway:
MAPK1/MAPK3
→
ELK1
(protein-protein, activation)
-
KEGG GnRH signaling pathway:
MAPK1/MAPK3
→
ELK1
(protein-protein, activation)
-
KEGG MAPK signaling pathway:
MAPK1/MAPK3
→
ELK1
(protein-protein, phosphorylation)
-
KEGG Prion diseases:
MAPK1/MAPK3
→
ELK1
(protein-protein, activation)
-
KEGG Leishmaniasis:
MAPK1/MAPK3
→
ELK1
(protein-protein, activation)
-
KEGG Endometrial cancer:
MAPK1/MAPK3
→
ELK1
(protein-protein, activation)
-
KEGG ErbB signaling pathway:
MAPK1/MAPK3
→
ELK1
(protein-protein, activation)
-
NCI Pathway Database Ras signaling in the CD4+ TCR pathway:
ELK1 (ELK1)
→
Erk1-2-active (MAPK3/MAPK1)
(modification, collaborate)
Gille et al., EMBO J 1995*, Rao et al., Oncogene 1994*
Evidence: assay, physical interaction
-
NCI Pathway Database Ras signaling in the CD4+ TCR pathway:
ELK1 (ELK1)
→
ERK1-2/ELK1 complex (MAPK3_MAPK1-ELK1)
(modification, collaborate)
Gille et al., EMBO J 1995*, Rao et al., Oncogene 1994*
Evidence: assay, physical interaction
-
NCI Pathway Database Ras signaling in the CD4+ TCR pathway:
Erk1-2-active (MAPK3/MAPK1)
→
ERK1-2/ELK1 complex (MAPK3_MAPK1-ELK1)
(modification, collaborate)
Gille et al., EMBO J 1995*, Rao et al., Oncogene 1994*
Evidence: assay, physical interaction
-
NCI Pathway Database Downstream signaling in naïve CD8+ T cells:
ELK1 (ELK1)
→
Erk1-2-active (MAPK3/MAPK1)
(modification, collaborate)
Gille et al., EMBO J 1995*, Rao et al., Oncogene 1994*
Evidence: assay, physical interaction
-
NCI Pathway Database Downstream signaling in naïve CD8+ T cells:
ELK1 (ELK1)
→
ERK1-2/ELK1 complex (MAPK3_MAPK1-ELK1)
(modification, collaborate)
Gille et al., EMBO J 1995*, Rao et al., Oncogene 1994*
Evidence: assay, physical interaction
-
NCI Pathway Database Downstream signaling in naïve CD8+ T cells:
Erk1-2-active (MAPK3/MAPK1)
→
ERK1-2/ELK1 complex (MAPK3_MAPK1-ELK1)
(modification, collaborate)
Gille et al., EMBO J 1995*, Rao et al., Oncogene 1994*
Evidence: assay, physical interaction
-
Reactome Reaction:
MAPK1
→
ELK1
(reaction)
-
WikiPathways ERK Pathway in Huntington's Disease:
MAPK1
→
ELK1/CREB1
(activation)
-
WikiPathways ESC Pluripotency Pathways:
MAPK7/MAPK1/MAPK6/MAPK4/MAPK12
→
JUN/ELK1/FOS
(activation)
-
WikiPathways ErbB Signaling Pathway:
MAPK1
→
ELK1/MYC
(activation)
-
WikiPathways Estrogen signaling pathway:
MAPK1
→
ELK1
(activation)
-
WikiPathways Focal Adhesion:
MAPK4/MAPK7/MAPK12/MAPK1/MAPK6
→
ELK1
(activation)
-
WikiPathways MAPK Cascade:
MAPK3/MAPK1
→
MBP/MAP2/ELK1
(activation)
-
WikiPathways PDGF Pathway:
MAPK1/MAPK3
→
ELK1
(mim-stimulation)
-
WikiPathways Serotonin Receptor 2 and ELK-SRF/GATA4 signaling:
MAPK1
→
ELK1
(mim-necessary-stimulation)
Vasilevskaya et al., Cancer Res 1999*, Li et al., Blood 2000*, Guha et al., Blood 2001*
-
WikiPathways Serotonin Receptor 4/6/7 and NR3C Signaling:
MAPK1
→
ELK1
(mim-necessary-stimulation)
Vasilevskaya et al., Cancer Res 1999*, Li et al., Blood 2000*, Guha et al., Blood 2001*
-
WikiPathways Signaling of Hepatocyte Growth Factor Receptor:
MAPK1/MAPK3
→
ELK1
(activation)
-
WikiPathways Structural Pathway of Interleukin 1 (IL-1):
MAPK3/MAPK1
→
ELK1
(activation)
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Bind_translation Interaction:
ELK1
—
MAPK1
(experimental interaction detection)
Zhu et al., Oncogene 2005*
-
IRef Biogrid Interaction:
ELK1
—
MAPK1
(physical association, affinity chromatography technology)
Zhu et al., Oncogene 2005*
-
IRef Biogrid Interaction:
ELK1
—
MAPK1
(physical association, affinity chromatography technology)
Tapinos et al., Proc Natl Acad Sci U S A 2005*
-
IRef Biogrid Interaction:
ELK1
—
MAPK1
(direct interaction, enzymatic study)
Eliopoulos et al., J Biol Chem 2006
-
IRef Biogrid Interaction:
ELK1
—
MAPK1
(direct interaction, enzymatic study)
Ho et al., J Biol Chem 2003
-
IRef Biogrid Interaction:
ELK1
—
MAPK1
(direct interaction, enzymatic study)
Eblen et al., J Biol Chem 2003*
-
IRef Biogrid Interaction:
ELK1
—
MAPK1
(direct interaction, enzymatic study)
Cano et al., J Cell Sci 1995*
-
IRef Biogrid Interaction:
ELK1
—
MAPK1
(direct interaction, pull down)
Cano et al., J Cell Sci 1995*
-
IRef Biogrid Interaction:
ELK1
—
MAPK1
(direct interaction, enzymatic study)
Han et al., Mol Endocrinol 2010*
-
IRef Biogrid Interaction:
ELK1
—
MAPK1
(direct interaction, enzymatic study)
Himpel et al., J Biol Chem 2000
-
IRef Biogrid Interaction:
ELK1
—
MAPK1
(physical association, affinity chromatography technology)
Zhang et al., PLoS Genet 2011*
-
IRef Biogrid Interaction:
ELK1
—
MAPK1
(direct interaction, enzymatic study)
Basaki et al., Arch Biochem Biophys 2002*
-
IRef Biogrid Interaction:
ELK1
—
MAPK1
(direct interaction, pull down)
Iwata et al., J Neurochem 2001*
-
IRef Biogrid Interaction:
ELK1
—
MAPK1
(direct interaction, enzymatic study)
Corbit et al., J Biol Chem 2003*
-
IRef Biogrid Interaction:
ELK1
—
MAPK1
(direct interaction, enzymatic study)
Bourguignon et al., J Biol Chem 2005*
-
IRef Biogrid Interaction:
ELK1
—
MAPK1
(direct interaction, enzymatic study)
Ahmed et al., Oncogene 2002*
-
IRef Biogrid Interaction:
ELK1
—
MAPK1
(direct interaction, enzymatic study)
Janknecht et al., EMBO J 1997*
-
IRef Biogrid Interaction:
ELK1
—
MAPK1
(direct interaction, enzymatic study)
Cavigelli et al., EMBO J 1995*
-
IRef Hprd Interaction:
ELK1
—
MAPK1
(in vitro)
Eliopoulos et al., J Biol Chem 2006, Rao et al., Oncogene 1994*, Marais et al., Cell 1993*, Cano et al., J Cell Sci 1995*
-
IRef Innatedb Interaction:
ELK1
—
MAPK1
(unknown, -)
Bourguignon et al., J Biol Chem 2005*
-
IRef Innatedb Interaction:
ELK1
—
MAPK1
(unknown, -)
Tapinos et al., Proc Natl Acad Sci U S A 2005*
-
IRef Intact Interaction:
ELK1
—
MAPK1
(phosphorylation reaction, protein kinase assay)
Eliopoulos et al., J Biol Chem 2006
-
IRef Ophid Interaction:
ELK1
—
MAPK1
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
-
IRef Ophid Interaction:
ELK1
—
MAPK1
(aggregation, confirmational text mining)
Rao et al., Oncogene 1994*
Text-mined interactions from Literome
Majka et al., Eur J Haematol 2000
(Leukemia-Lymphoma, Adult T-Cell) :
Activation of
MAPK further
led to the phosphorylation of the nuclear transcription factor
ELK-1
Duan et al., J Biol Chem 2001
:
Estrogen receptor mediated activation of the serum response element in MCF-7 cells through
MAPK dependent phosphorylation of
Elk-1
Chung et al., FASEB J 2001
:
This inhibition of
Erk1/2 activity is
Elk-1 concentration
dependent and ATP concentration independent, which suggests that EGCG and TFdiG interfere with the binding of the protein substrate to the kinase
Woo et al., J Clin Endocrinol Metab 2001
:
In summary, our studies demonstrate, for the first time, that melatonin can regulate progesterone production, LH receptor, GnRH, and GnRH receptor gene expression through melatonin receptors in human granulosa-luteal cells, which may be mediated via the
MAPK pathway and
activation of
Elk-1
Stevens et al., Science 2002
(MAP Kinase Signaling System) :
Knock-out of Sur2 prevents activation by E1A-CR3 and the
mitogen activated protein kinase regulated ETS transcription factor
Elk-1 , but not by multiple other transcription factors
Bea et al., Circ Res 2003
(MAP Kinase Signaling System) :
Furthermore, C pneumoniae stimulated phosphorylation of ERK1/2 and
Elk-1 and pharmacological inhibition of
mitogen activated protein kinase activity
reduced the expression of TF and Egr-1
Chen et al., J Cell Biochem 2004
:
Egr-1 is activated by 17beta-estradiol in MCF-7 cells by
mitogen activated protein kinase dependent phosphorylation of
ELK-1
Vlotides et al., Mol Endocrinol 2006
(Pituitary Neoplasms) :
EGF induced EGFR and ERK1/2 phosphorylation was followed by rapid
MAPK kinase/ERK kinase dependent
activation of
Elk-1 and c-Fos
Muddasani et al., J Biol Chem 2007
:
Taken together, our results suggest that elevated expression of MMP-13 occurs through
Elk-1 activation of both
MAPK and NFkappaB signaling pathways, thus revealing a two pronged biological mechanism by which bFGF controls the production of catabolic enzymes that are associated with excessive degradation of the cartilage matrix in degenerative joint diseases such as osteoarthritis
Wang et al., Neurotox Res 2010
:
Here, we reported that oxLDL induced MMP-9 expression via a PKC-delta/p42/p44
MAPK dependent
Elk-1 activation in rat brain astrocyte ( RBA ) -1 cells, revealed by gelatin zymography, RT-PCR, and Western blotting analyses
Müller et al., Eur J Biochem 1997
:
A temporal correlation is observed between changes in the phosphorylation status of
Elk-1 and the
activation of the
mitogen activated protein kinase 2 ( ERK2 ) in response to cellular redox changes