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CA2 — STC1
Text-mined interactions from Literome
Gagliardi et al., Am J Physiol Endocrinol Metab 2005
(Body Weight...) :
Serum Ca2+ and PO4 were unchanged in hSTC-2-transgenic mice, although
STC-1 can
regulate intra- and extracellular
Ca2+ in mammals
Xiao et al., Reproduction 2005
:
Meanwhile, another
Ca2+ regulated gene
stanniocalcin-1 (STC-1) has been documented to be involved in decidualization and uterine remodelling
Hanssen et al., Gen Comp Endocrinol 1991
(Hypercalcemia) :
High levels of
Ca2+ ( 2.5 mM and higher ), however,
stimulate the release of
STC , in particular that of stored STC
Shin et al., Zoolog Sci 2008
:
Molecular cloning of
stanniocalcin 1 and its extracorpuscular
regulation by salinity and
Ca2+ in the Japanese flounder ... Furthermore, we found that extracellular
Ca2+ increased steady-state
stc1 mRNA levels in gill and kidney cells as well as in the CS cells
Wagner et al., Mol Cell Endocrinol 1991
:
Previous in vitro studies by our laboratory have shown that
STC secretion is positively
regulated by
Ca2+ in a time- and dose dependent fashion
Ellis et al., J Biol Chem 1995
:
The purpose of this study was to determine the
effects of
Ca2+ on
STC mRNA stability ... These data demonstrate that the stimulatory
effect of
Ca2+ on
STC gene expression is due, in part, to mRNA stabilization
Wagner et al., Am J Physiol 1998
:
High levels of extracellular
Ca2+ promote the synthesis and release of
STC , which on entering the bloodstream reduces the levels of gill and gut Ca2+ transport and renal phosphate excretion to restore normocalcemia