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EPHB2 — HRG
Text-mined interactions from Literome
Sun et al., J Cell Physiol 2002
(Breast Neoplasms) :
The activation of both
ERK and PI3-K was
essential for
HRG regulation of COXII, i.e., blockage of either pathway eliminated HRG mediated alteration
Yang et al., Mol Cell Biol 2006
(Breast Neoplasms) :
Furthermore, inactivation of Rac by expression of the Rac GTPase activating protein beta2-chimerin inhibited
HRG induced
ERK activation, mitogenicity, and migration in breast cancer cells
Bourguignon et al., J Biol Chem 2007
(MAP Kinase Signaling System...) :
Taken together, these findings clearly indicate that
HRG activation of
ErbB2-ERK signaling modulates HAS phosphorylation/activation and HA production leading to CD44 mediated oncogenic events and ovarian cancer progression
Gui et al., Mol Cell Biochem 2007
:
Akt and
ERK were
activated by
HRG under SD and hypoxia conditions, but HRG had no effects on the activation of JNK and p38
Tang et al., J Nutr Biochem 2008
(Breast Neoplasms...) :
Furthermore, resveratrol significantly suppressed
HRG-beta1 mediated phosphorylation of
ERK1/2 and invasion of breast cancer cells
Birtwistle et al., Molecular systems biology 2007
:
Model analysis and experimental validation show that ( i ) ErbB2 overexpression, which occurs in approximately 25 % of all breast cancers, transforms transient EGF induced signaling into sustained signaling, ( ii )
HRG induced
ERK activity is much more robust to the ERK cascade inhibitor U0126 than EGF induced ERK activity, and ( iii ) phosphoinositol-3 kinase is a major regulator of post-peak but not pre-peak EGF induced ERK activity
Yonezawa et al., Digestion 2009
(Adenocarcinoma...) :
HRG also
activated p85 PI-3K, Akt,
ERK1/2 , and p38 MAPK
Nakakuki et al., Cell 2010
:
In the cytosol, EGF induces transient and
HRG induces sustained
ERK activation
Lessor et al., J Cell Biochem 1998
(Breast Neoplasms) :
A MEK specific inhibitor, PD98059, which inhibited activation of
ERK in
response to
HRG , completely blocked HRG induced differentiation and reversed cell growth arrest