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AKT2 — ANGPT1

Text-mined interactions from Literome

Fujikawa et al., Exp Cell Res 1999 : Ceramide induced endothelial cell death and abolished angiopoietin-1 mediated activation of Akt and the effect on cell survival
Chen et al., J Appl Physiol 2004 : Ang-1 also led to stimulation of HSP90 binding to eNOS and a significant increase in Akt phosphorylation
Pyriochou et al., Br J Pharmacol 2007 : On the other hand, C-18 blocked activation of members of the mitogen activated protein kinase family and of the Ser/Thr kinase Akt induced by both VEGF and Ang-1
Chen et al., Arterioscler Thromb Vasc Biol 2008 (Diabetes Mellitus, Type 2...) : These alterations led to a significant impairment of Ang-1 induced Akt and eNOS phosphorylation, along with a remarkable impairment of Ang-1 induced endothelial cell migration and endothelial cell spheroid sprouting
Onimaru et al., Arterioscler Thromb Vasc Biol 2010 (Disease Models, Animal...) : A soluble form of Tie-2 produced in human umbilical vein endothelial cells was dramatically suppressed by treatment with siRNA-matrix metalloproteinase (MMP) 14 or tissue inhibitor of metalloproteinase 3, resulting in an increase in cellular fTie-2 and thereby enhancing Ang-1 dependent Akt phosphorylation and Akt dependent endothelial functions, such as Ang-2 downregulation or an increase of endothelial viability
Thomas et al., J Biol Chem 2010 : However, only Ang-1 induces Tie2 dependent Akt activation and subsequent survival signaling and endothelial quiescence
Chen et al., Exp Diabetes Res 2012 (Diabetes Mellitus, Type 2) : Treatment with PTP inhibitors restored Ang-1 induced Akt/eNOS phosphorylation and angiogenesis