Akakura et al., Exp Cell Res 2004
:
The opsonin MFG-E8 is a ligand for the alphavbeta5 integrin and triggers DOCK180 dependent Rac1 activation for the phagocytosis of apoptotic cells ... Coexpression of MFG-E8 with alphavbeta5 integrin potentiated integrin mediated Rac1 activation, which was abrogated by mutagenesis in the RGD motif in MFG-E8
Mao et al., Mol Biol Cell 2012
:
Quantification of active GTP-Rac1 in wild-type and mutant RPE in culture and in vivo revealed that Rac1 activation during phagocytosis requires avß5 integrin and its ligand milk fat globule EGF factor-8 (MFG-E8) but not the receptor tyrosine kinase MerTK