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FOXP3 — IL6

Text-mined interactions from Literome

Yao et al., Blood 2007 : Reduction of Stat3 in T cells did not reduce the numbers of Treg cells in the thymus or spleen ; however, Stat3 was required for IL-6 dependent down-regulation of Foxp3
Bettelli et al., Nat Immunol 2007 (Autoimmune Diseases) : These data suggest a dichotomy between CD4 ( + ) regulatory T cells positive for the transcription factor Foxp3 and T ( H ) -17 cells : TGF-beta induces Foxp3 and generates induced regulatory T cells, whereas IL-6 inhibits TGF-beta-driven Foxp3 expression and together with TGF-beta induces T ( H ) -17 cells
Kimura et al., Proc Natl Acad Sci U S A 2007 : We demonstrate here that IL-6 , but not TNF-alpha or IL-1beta, can, in combination with TGF-beta, induce Th17 cell generation from naïve T cells and inhibit TGF-beta induced Foxp3 expression
Hinz et al., Cancer Res 2007 (Carcinoma...) : Down-regulation of Foxp3 with small interfering RNA ( siRNA ) in pancreatic carcinoma cells resulted in the up-regulation of interleukin 6 (IL-6) and IL-8 expression, providing evidence for a negative transcriptional activity of Foxp3 also in these epithelial cells
Ichiyama et al., J Biol Chem 2008 : IL-6 reduced Foxp3 expression, and overexpression of Foxp3 in a T cell line resulted in a strong reduction of IL-17A expression
Kattah et al., Arthritis Rheum 2008 : IL-6 suppressed the expression of forkhead box P3 and reversed TGFbeta mediated inhibition of T cell proliferation, but did not trigger IL-17 secretion
Xiao et al., J Immunol 2008 (Autoimmune Diseases) : Herein we show that RA enhances TGF-beta signaling by increasing the expression and phosphorylation of Smad3, and this results in increased Foxp3 expression even in the presence of IL-6 or IL-21
Radhakrishnan et al., J Immunol 2008 (Multiple Myeloma) : Down-regulation of FoxP3 expression after either in vitro or in vivo Treg-DC ( XAb ) interaction is Ag-specific, IL-6 dependent , and results in the functional reprogramming of the mature T cell phenotype
Chaput et al., Gut 2009 (Adenocarcinoma...) : Finally, interleukin 6 and TGF beta 1 synergistically induced the generation of CD8 ( + ) CD25 ( + ) Foxp3 ( + ) T cells ex vivo
Lal et al., J Immunol 2009 (Autoimmune Diseases...) : Conversely, IL-6 resulted in methylation of this site and repression of Foxp3 expression
Mus et al., Arthritis Rheum 2010 (Arthritis, Experimental) : In contrast, transforming growth factor beta1 ( TGFbeta1 ) /IL-6 was a potent inducer of RORgammat, RORalpha, IL-17A, IL-17F, IL-21, and FoxP3 in these cells
Fogal et al., J Immunol 2011 (Disease Models, Animal) : Neutralizing IL-6 in primary allogeneic T cell-EC cocultures results in enhanced T cell proliferation of CD161 ( + ) CD4 ( + ) T cells, reduces total T cell proliferation upon restimulation in secondary cultures ( an effect dependent on CD161 ( + ) T cells ), increases expression of FOXP3 in CD161 ( + ) T cells, and generates T cells that suppress proliferation of freshly isolated T cells
Liu et al., Eur J Immunol 2013 (Colitis) : Inhibition of ERK decreased IL-6 induction of RAR related orphan receptor ?t but enhanced TGF-ß induction of Foxp3 , and ERK inhibitor treated T cells under Th17 conditions possessed suppressive function in vitro because they produced more IL-10 and TGF-ß and inhibited naïve T-cell proliferation and IFN-? production at levels comparable with that of Treg cells