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GNA12 — MAPK13
Text-mined interactions from Literome
Dermott et al., Oncogene 2004
(Cell Transformation, Neoplastic) :
In the present studies, we show that the stimulation of Galpha(12)WT or the expression of Galpha(12)QL results in a potent inhibition of p38MAPK, and that the mechanism by which
Galpha(12) inhibits
p38MAPK activity involves the dual specificity kinases upstream of p38MAPK ... These findings demonstrate for the first time that
Galpha(12) differentially
regulates JNK and
p38MAPK by specifically activating MKK7, while inhibiting MKK3 and MKK4 in NIH3T3 cells
Kinane et al., Am J Physiol 1997
:
Expression of a guanosinetriphosphatase ( GTPase ) -deficient
G alpha(i-2) in these cells
increased MAPK ( p42/p44 ) activity and correspondingly reduced cell doubling time from 24 to 10 h without altering the activity of Raf-1 or c-Jun/stress activated protein kinases ( SAPKs )
Denis-Henriot et al., Endocrinology 1998
:
In confluent preadipocytes, expression of the activated mutant of
Galpha12 induced an increase in B-Raf expression, but no change in
MAPK activity ... Wild-type
Galpha12 overexpression
prevented the decrease in
MAPK activity and induced MEK1, but not B-Raf, expression