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IFNG — PI3

Text-mined interactions from Literome

Sutherland et al., J Immunol 2002 (MAP Kinase Signaling System) : ULBP induced activation of Akt and extracellular signal regulated kinase and ULBP induced IFN-gamma production are blocked by inhibitors of PI 3-kinase , consistent with the known binding of PI 3-kinase to DAP10, the membrane bound signal transducing subunit of the NKG2D receptor
Khan et al., J Neurovirol 2003 : Tat activated KDR in the presence of IFN-gamma , and Tat mediated cytopathic changes involve its interaction with KDR and phosphatidylinositol 3-kinase (PI3K)
Tassi et al., Immunity 2007 : p110gamma played a major role in receptor induced interferon-gamma (IFN-gamma) production through a pathway that involved the kinase ERK and 5-Lipoxigenase, which most likely generates lipid mediators activating GPRCs. Conversely, PI3Ks negatively regulated interleukin-12 (IL-12) and IL-18 induced IFN-gamma by modulating p38 kinase activation