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NOS2 — NPY4R

Text-mined interactions from Literome

Orlicek et al., Shock 1999 : The src family-selective tyrosine kinase inhibitor PP1 blocks LPS and IFN-gamma mediated TNF and iNOS production in murine macrophages ... We report that the pyrazolopyrimidine PP1 , a src family-selective tyrosine kinase inhibitor, potently inhibits the production of TNF and inducible nitric oxide synthase (iNOS) in RAW 264.7 murine macrophages stimulated with LPS, rlFN-gamma, or LPS + rIFN-gamma
Stovall et al., J Biol Chem 2004 : PP1 , a selective inhibitor of src related tyrosine kinases, blocked both the CpG DNA mediated tyrosine phosphorylation of vav1 and the CpG DNA mediated up-regulation of macrophage tumor necrosis factor secretion and inducible nitric-oxide synthase protein accumulation
Lee et al., Biochem Pharmacol 2005 : Moreover, PP1 suppressed the expression of IFNbeta and iNOS induced by TRIF, a MyD88 independent adaptor of TLR4
Kox et al., Vascul Pharmacol 2007 : LPS also increased levels of iNOS and this was also inhibited by SU6656 and PP1
Hirji et al., J Immunol 1998 : Genistein ( broad spectrum protein tyrosine kinase inhibitor, 10 microg/ml ), PP1 ( src family kinase inhibitor, 5 microg/ml ), polymyxin B ( protein kinase C ( PKC ) inhibitor, 100 microg/ml ), and Ro 31-8220 ( PKC inhibitor, 1 microM ) significantly inhibited anti-CD8alpha- and anti-CD8beta stimulated NO production and inducible NO synthase up-regulation, suggesting that tyrosine kinase ( s ) ( src family ) and PKC are involved in CD8 signaling