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CSF2 — IL12B

Text-mined interactions from Literome

Takayama et al., J Invest Dermatol 1999 : Both GM-CSF and TNF-alpha induced the migration of human Langerhans cells in vitro, whereas IL-1beta, IL-2, IL-10, IL-12 , and IFN-gamma had no effect on Langerhans cell migration
Tada et al., J Immunol 2000 : Granulocyte/macrophage colony stimulating factor inhibits IL-12 production of mouse Langerhans cells ... Surprisingly, GM-CSF strikingly inhibited IL-12 p40 production by anti-CD40/IFN-gamma stimulated LC ( % inhibition = 97.0 +/- 0.9 % at 1 ng/ml GM-CSF ) ... IL-1alpha ( 1 ng/ml ) -stimulated KC produced much more GM-CSF than unstimulated KC ( 60.9 +/- 0.2 pg/ml vs 20.9 +/- 1.7 pg/ml ), and IL-1alpha stimulated KC supernatants strongly inhibited IL-12 p40 production by anti-CD40/IFN-gamma stimulated LC ( % inhibition = 89.4 +/- 1.4 % )
Tada et al., Eur J Immunol 2001 : More importantly, it was found that in contrast to TGF-beta, granulocyte/macrophage colony stimulating factor ( GM-CSF ) strikingly inhibits IL-12 production of anti-CD40/IFN -- stimulated LC and that the level of LC IL-12 production is determined by the relative amounts of TGF-beta1 and GM-CSF
Dai et al., Immunology 2001 : These findings demonstrated the ability of GL to enhance LPS induced IL-12 production by peritoneal macrophages, and indicated that the priming effect of GL on IL-12 production was independent of both IFN-gamma and GM-CSF
Lissoni et al., J Biol Regul Homeost Agents 2001 (Neoplasms...) : Stimulation of IL-12 secretion by GM-CSF in advanced cancer patients ... Unfortunately, at present there are only few and controversial results on GM-CSF effects on IL-12 secretion in cancer patients ... This preliminary study seems to show that GM-CSF may acutely stimulate IL-12 secretion in cancer patients ... Further studies are required to evaluate the effects of chronic GM-CSF administration, and the impact of GM-CSF induced secretion of IL-12 on the efficacy of the immunotherapies of cancer with cytokines, such as IL-2
Moore et al., J Virol 2002 : IL-12 induced the greatest increase in IFN-gamma and immunoglobulin G responses to Nef, and GM-CSF induced the strongest IFN-gamma and CTL responses to Env
Bolacchi et al., Cytokine 2001 : Here we show that CD40L ( ligand for CD40 ) failed to induce the production of tumour necrosis factor alpha (TNF-alpha), interleukin (IL-)-1 beta, IL-10 and IL-12 in macrophages matured in vitro in the absence of growth factors or in the presence of macrophage colony stimulating factor ( M-CSF )
Perez et al., Blood 2003 (Burkitt Lymphoma...) : FL plus IL-15-driven ACF/CD56 ( + ) cells progressively expressed a mature NK functional program lysing both NK- and lymphokine-activate killer ( LAK ) -sensitive tumor targets and producing high levels of interferon-gamma (IFN-gamma), granulocyte-macrophage colony stimulating factor , tumor necrosis factor alpha, and IL-10 upon stimulation with IL-12 and IL-18
Harada et al., J Interferon Cytokine Res 2004 : In contrast, neutralizing GM-CSF using anti-GM-CSF monoclonal antibody ( mAb ) significantly inhibited IFN-gamma, TNF-alpha, and IL-12p70 elicited by SCG
Li et al., Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi 2004 (Malaria, Falciparum) : GM-CSF , IL-4 and IL-12 encoding plasmids all promoted mice immune response to VR1020/E, the antibody level increased 7 to 10 times and splenocyte proliferation was enhanced too
Oishi et al., Cytokine 2006 : The rhG-CSF induced a pre-PHx downregulation of the IL-12p70 protein levels, while also promoting the post-PHx reduction of the protein levels of IL-12p70 and IFN-gamma
Harada et al., Microbiol Immunol 2006 (Leukopenia) : Neutralizing GM-CSF significantly inhibited the induction of IFN-gamma, TNF-alpha and IL-12p70 by SCG
Eksioglu et al., Exp Hematol 2007 (Inflammation) : We investigated the hypothesis that granulocyte-macrophage colony stimulating factor ( GM-CSF ) induces IL-12 production and polarizes T lymphocytes toward a proinflammatory response
Ochoa-Repáraz et al., Infect Immun 2007 (Q Fever...) : Cytokine analysis was performed on infected peritoneal macrophages isolated from these mice, and immunocompetent macrophages showed robust tumor necrosis factor alpha, IFN-gamma, and granulocyte-macrophage colony stimulating factor ( GM-CSF ) but no interleukin-12 (IL-12) responses
Nishimura et al., J Parasitol 2008 : These results suggest that the WS inhibits IL-12p40 mRNA production by promoting production of macrophage colony stimulating factor by macrophages
Enríquez-de-Salamanca et al., Cytokine 2008 (Conjunctivitis, Allergic...) : TNF-alpha stimulated secretion of IL-12p40 was significantly increased by 30 min ; GM-CSF , MCP-1, IL-6, IL-7, IL-8, and RANTES were significantly increased by 2 h, and IFN-gamma and IL-1alpha by 24 h
Sonderegger et al., J Exp Med 2008 (Autoimmune Diseases...) : We found that innate GM-CSF was critical for IL-6 and IL-23 responses by dendritic cells and generation of pathological Th17 cells in vivo
Wong et al., J Immunol 2009 : IL-12p70 production was produced predominantly by CD8alpha ( + ) DCs and plasmacytoid DCs, and mediated by CD8 T cell derived cytokines IFN-gamma, GM-CSF , TNF-alpha, and surface CD40L
van de Wetering et al., PloS one 2009 (Salmonella Infections) : In addition, IL-23 together with IL-18 or IL-1beta led to the production of GM-CSF in CD56 ( + ) cells ... Both IFN-gamma and GM-CSF enhanced IL-23 production by monocytes in response to TLR agonists, as well as induced IL-12 production
Martins et al., J Leukoc Biol 2011 : GR-1 CM and rG-CSF also inhibited LPS induced IL-12 production at the mRNA and protein levels
El-Behi et al., Nat Immunol 2011 (Encephalomyelitis, Autoimmune, Experimental) : Here we found that IL-23 induced production of the cytokine granulocyte-macrophage colony stimulating factor ( GM-CSF ) in T ( H ) 17 cells and that GM-CSF had an essential role in their encephalitogenicity ... IL-23 induced a positive feedback loop whereby GM-CSF secreted by T ( H ) 17 cells stimulated the production of IL-23 by antigen presenting cells
Spear et al., J Immunol 2012 (Neoplasms, Experimental) : T cell IFN-? and GM-CSF activated local, tumor associated macrophages, decreased expression of regulatory factors, increased IL-12p40 production, and augmented Ag processing and presentation by host macrophages to Ag-specific T cells
La Flamme et al., PloS one 2012 : Instead, we found that derivation culture conditions ( GM-CSF plus IL-3 versus M-CSF ) could explain the different responses of BALB/c and IL-4Ra-/- macrophages, and these cytokines shaped the ensuing macrophage such that GM-CSF plus IL-3 promoted more IL-12 and IL-4 while M-CSF led to higher IL-10 production
Souza-Fonseca-Guimaraes et al., J Biol Chem 2013 (MAP Kinase Signaling System) : Using knock-out-mice, we show that UNC93b1 and IL-12 ( produced by NK cells themselves ) are also necessary for IFN-? and GM-CSF production
Kubin et al., J Exp Med 1994 : The proliferative effect of anti-CD28 and IL-12 is resistant to moderate doses of cyclosporin A and is largely independent of endogenous IL-2, IL-12, in synergy with anti-CD28 or B7-transfected cells, is most effective in inducing interferon gamma (IFN-gamma) production, but production of tumor necrosis factor alpha and granulocyte/macrophage colony stimulating factor is also observed
Cesano et al., Cancer Immunol Immunother 1995 : CsA did not impair the ability of TALL-104 and LAK cells to produce interferon (IFN) gamma, tumor necrosis factor (TNF) alpha, and granulocyte/macrophage-colony-stimulatory factor ( GM-CSF ) in response to IL-2, IL-12 , or tumor targets
Aste-Amezaga et al., Cell Immunol 1994 : It was found that IL-12 induces mRNA accumulation and production of GM-CSF and TNF-alpha from both T and NK cells and, as tested on NK cells only, induces M-CSF mRNA accumulation
Micallef et al., Eur J Immunol 1996 : IGIF, but not IL-12 , significantly enhanced IL-2 and GM-CSF production in T cell cultures, as determined by CTLL-2 bioassay and ELISA, respectively ; however, both IGIF and IL-12 enhanced IFN-gamma production by the T cells
Pulendran et al., J Immunol 1997 : These DC subpopulations showed different capacities to phagocytose FITC-zymosan and to secrete IL-12 upon stimulation with Staphylococcus aureus cowan I strain + IFN-gamma + granulocyte-macrophage-CSF
Okano et al., Int Arch Allergy Immunol 1998 (Asthma) : We examined the effects of IL-12 on the productions of IL-5 and granulocyte/macrophage colony stimulating factor ( GM-CSF ) by antigen ( Dermatophagoides farinae, Df ) -stimulated mononuclear cells ( MNCs ) from asthmatic patients in vitro ... IL-12 enhanced IFN-gamma production and inhibited the production of IL-5 but not of GM-CSF by Df-stimulated MNCs from asthmatic patients
Grewe et al., J Immunol 1998 : The expression of both IL-12 protein and mRNAs for the p35 and p40 IL-12 subunits was strongly induced in all donors by the Th2-like cytokines IL-4 and granulocyte-macrophage CSF and was also moderately induced by TNF-alpha and IL-1alpha