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EDN3 — MAPK12
Text-mined interactions from Literome
Nilsson et al., Eur J Pharmacol 2008
(Cardiovascular Diseases) :
We hypothesize that protein kinase C ( PKC ) and mitogen activated kinases (
MAPK ) are
involved in the regulation of
endothelin receptors
Eriksson et al., J Ethnopharmacol 2008
:
We also demonstrate that Panax ginseng,
endothelin-3 (ET-3) and alpha-melanocyte stimulating hormone ( MSH )
stimulate an activation of
mitogen activated protein kinase ( MAPK ) ... Pre-incubation with M-EGF decreased the
MAPK activity
induced by
ET-3 and MSH, but again only marginally affected the response of Panax ginseng
Nilsson et al., BMC cardiovascular disorders 2008
:
The
involvement of PKC and
MAPK in the
endothelin receptor regulation was examined by culture in the presence of antagonists
Kalabis et al., Am J Physiol Gastrointest Liver Physiol 2008
:
ET3 induced activation of IkappaB and
MAPK in the epithelial cells, suggesting that these signaling pathways mediate its proproliferation and prosurvival activities
Chen et al., BMC cell biology 2009
:
Role of
ERK/MAPK in
endothelin receptor signaling in human aortic smooth muscle cells
Sandhu et al., Toxicol Appl Pharmacol 2010
:
The present study was designed to examine if lipid-soluble ( dimethyl sulfoxide-soluble ) cigarette smoke particles ( DSP ) induces upregulation of contractile endothelin type B ( ET ( B ) ) receptors in rat cerebral arteries and if activation of mitogen activated protein kinase (
MAPK ) and nuclear factor-kappaB ( NF-?B )
mediate the upregulation of contractile
endothelin receptors in the cerebral arteries
Zhang et al., TheScientificWorldJournal 2010
(Cardiovascular Diseases...) :
Up-regulation of
endothelin receptors
induced by cigarette smoke -- involvement of
MAPK in vascular and airway hyper-reactivity
Lazou et al., Circ Res 1994
:
In isolated myocytes,
endothelin 1 ( 100 nmol/L for 5 minutes ) also
stimulated MAPK , but stimulation by norepinephrine or isoproterenol was difficult to detect
Sugimoto et al., Biochem Biophys Res Commun 1993
:
In cultured rat glomerular mesangial cells,
endothelin-1 (ET-1)
activated both pp 44 and pp 42
mitogen activated protein ( MAP ) kinases
Jones et al., Life Sci 1996
:
Effects of
endothelin on
mitogen activated protein kinase activity and protein synthesis in isolated adult feline cardiac myocytes
Scott et al., Biochem J 1996
:
In bovine airway smooth-muscle cells platelet derived growth factor ( PDGF ) and
endothelin ( Et-1 )
stimulate sustained and comparable activation of
mitogen activated protein kinase ( MAP kinase ) but display very different mitogenic efficacies, with PDGF inducing 50 times more DNA synthesis than Et-1